Overview

  • Product name

    ITE
  • Description

    An endogenous aryl hydrocarbon receptor (AhR) agonist
  • Alternative names

    • 2-(1H-Indol-3-ylcarbonyl)-4-thiazolecarboxylic acid methyl ester
  • Biological description

    Endogenous aryl hydrocarbon receptor (AhR) agonist (Ki = 3 nM). Enhances differentiation of cancer stem like cells detected by the decrease of sphere formation and proliferation from glioblastoma cells U87. Induces stem-like cancer cell differentiation in U87 tumor spheres and inhibits ovarian cancer cell proliferation in vitro. Suppresses tumor growth in U87 and OVCAR-3 cell xenografts in mice. Inhibits TGF-β-induced human myofibroblast differentiation.

  • Purity

    > 98%
  • General notes

    Protect from air and light.

  • CAS Number

    448906-42-1
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    Methyl 2-(1H-indole-3-carbonyl)-1,3-thiazole-4-carboxylate

  • Molecular weight

    286.31
  • Molecular formula

    C14H10N2O3S
  • PubChem identifier

    4668801
  • Storage instructions

    Shipped at 4°C. Store at -20°C long term. It is important to note that this is air sensitive and impurities can occur as a result of air oxidation. Store In the Dark.
  • Solubility overview

    Soluble in DMSO to 75 mM

  • Handling

    Refer to SDS for further information.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    COC(=O)C1=CSC(=N1)C(=O)C2=CNC3=CC=CC=C32
  • Source

    Synthetic

References

This product has been referenced in:

  • Dolciami D  et al. Binding Mode and Structure-Activity Relationships of ITE as an Aryl Hydrocarbon Receptor (AhR) Agonist. ChemMedChem 13:270-279 (2018). Read more (PubMed: 29266750) »
  • Wang K  et al. An endogenous aryl hydrocarbon receptor ligand inhibits proliferation and migration of human ovarian cancer cells. Cancer Lett 340:63-71 (2013). Read more (PubMed: 23851185) »
  • Lehmann GM  et al. The aryl hydrocarbon receptor ligand ITE inhibits TGFß1-induced human myofibroblast differentiation. Am J Pathol 178:1556-67 (2011). Read more (PubMed: 21406171) »
  • Song J  et al. A ligand for the aryl hydrocarbon receptor isolated from lung. Proc Natl Acad Sci U S A 99:14694-9 (2002). Read more (PubMed: 12409613) »

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab231512.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
For licensing inquiries, please contact partnerships@abcam.com

Sign up