Overview

  • Product name

  • Description

    Rabbit polyclonal to ITGA11
  • Host species

    Rabbit
  • Specificity

    This antibody detects endogenous levels of total ITGA11 protein.
  • Tested applications

    Suitable for: IHC-P, WBmore details
  • Species reactivity

    Reacts with: Mouse, Human
    Predicted to work with: Rat
  • Immunogen

    Synthetic peptide corresponding to Human ITGA11 (internal sequence).
    Database link: Q9UKX5

  • Positive control

    • Mouse skeletal muscle tissue lysate and human liver cancer tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab198826 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/50 - 1/200.
WB 1/200 - 1/1000. Predicted molecular weight: 133 kDa.

Target

  • Function

    Integrin alpha-11/beta-1 is a receptor for collagen.
  • Tissue specificity

    According to PubMed:10464311, highest levels of expression in uterus and heart, intermediate levels in skeletal muscle and intermediate to low levels in pancreas, kidney and placenta. According to PubMed:10486209, also found in brain, colon, lung, small intestine, stomach, testis, salivary glands, thyroid glands and prostate. Very low levels in peripheral blood lymphocytes, fetal brain and fetal liver.
  • Sequence similarities

    Belongs to the integrin alpha chain family.
    Contains 7 FG-GAP repeats.
    Contains 1 VWFA domain.
  • Developmental stage

    Strongly up-regulated in differentiating fetal muscle cells (in vitro).
  • Domain

    The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
  • Cellular localization

    Membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • integrin a11 antibody
    • Integrin alpha 11 antibody
    • Integrin alpha-11 antibody
    • ITA11_HUMAN antibody
    • ITGA11 antibody
    see all

Images

  • Immunohistochemical staining of paraffin-embedded human liver cancer tissue labeling ITGA11 using ab198826 at a 1/200 dilution.

  • Anti-ITGA11 antibody (ab198826) at 1/200 dilution + Mouse skeletal muscle tissue lysate at 40 µg

    Predicted band size: 133 kDa


    Exposure time: 3 minutes


    6% SDS PAGE

References

This product has been referenced in:

  • Shen B  et al. Integrin alpha11 is an Osteolectin receptor and is required for the maintenance of adult skeletal bone mass. Elife 8:N/A (2019). Read more (PubMed: 30632962) »
  • Xie X & Percipalle P Elevated transforming growth factor ß signaling activation in ß-actin-knockout mouse embryonic fibroblasts enhances myofibroblast features. J Cell Physiol N/A:N/A (2018). Read more (PubMed: 29851084) »
See all 2 Publications for this product

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