Overview

  • Product name
    Anti-ITGA8 antibody - C-terminal
    See all ITGA8 primary antibodies
  • Description
    Rabbit polyclonal to ITGA8 - C-terminal
  • Host species
    Rabbit
  • Tested applications
    Suitable for: IHC-P, WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide within Human ITGA8 aa 1032-1061 (C terminal) conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary.
    Database link: P53708

  • Positive control
    • K562 cell lysate, Human kidney tissue.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer
    Preservative: 0.09% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • Purity
    Protein A purified
  • Purification notes
    ab170464 is purified through a protein A column, followed by peptide affinity purification
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab170464 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
WB 1/100 - 1/500. Predicted molecular weight: 117 kDa.

Target

  • Function
    Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis. Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons.
  • Tissue specificity
    Expressed in mesenchymal cells, including alveolar myofibroblasts, kidney mesangial cells and hepatic stellar cells and vascular and visceral smooth muscle (at protein level).
  • Sequence similarities
    Belongs to the integrin alpha chain family.
    Contains 7 FG-GAP repeats.
  • Cellular localization
    Membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Integrin alpha 8 antibody
    • Integrin alpha-8 heavy chain antibody
    • Integrin alpha-8 light chain antibody
    • ITA8_HUMAN antibody
    • ITGA 8 antibody
    • ITGA8 antibody
    see all

Images

  • Immunohistochemical analysis of formalin-fixed paraffin-embedded Human kidney tissue, labeling ITGA8 using ab170464 at a 1/50 dilution, followed by peroxidase conjugation of the secondary antibody and DAB staining.

  • Anti-ITGA8 antibody - C-terminal (ab170464) at 1/100 dilution + K562 cell lysate at 35 µg

    Predicted band size: 117 kDa

References

ab170464 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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