Overview

  • Product name

  • Description

    Mouse polyclonal to ITIH1/SHAP
  • Host species

    Mouse
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Full length protein corresponding to Human ITIH1/SHAP.
    Database link: NP_002206.1

  • Positive control

    • ITIH1/SHAP transfected 293T cell lysate.
  • General notes

    Previously labelled as ITIH1

Properties

Applications

Our Abpromise guarantee covers the use of ab70048 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Detects a band of approximately 102 kDa (predicted molecular weight: 102 kDa).

Target

  • Function

    May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes.
    Contains a potential peptide which could stimulate a broad spectrum of phagocytotic cells.
  • Sequence similarities

    Belongs to the ITIH family.
    Contains 1 VIT domain.
    Contains 1 VWFA domain.
  • Post-translational
    modifications

    Heavy chains are linked to bikunin via chondroitin 4-sulfate esterified to the alpha-carboxyl of the C-terminal aspartate after propeptide cleavage.
    The S-linked glycan is composed of two 6-carbon sugars, possibly Glc or Gal.
  • Cellular localization

    Secreted.
  • Information by UniProt
  • Database links

  • Alternative names

    • H1P antibody
    • IATIH antibody
    • IGHEP1 antibody
    • Inter alpha (globulin) inhibitor H1 antibody
    • Inter alpha (globulin) inhibitor H1 polypeptide antibody
    • Inter alpha trypsin inhibitor heavy chain 1 antibody
    • Inter alpha trypsin inhibitor heavy chain H1 antibody
    • Inter-alpha-inhibitor heavy chain 1 antibody
    • Inter-alpha-trypsin inhibitor complex component III antibody
    • Inter-alpha-trypsin inhibitor heavy chain H1 antibody
    • ITI heavy chain H1 antibody
    • ITI-HC1 antibody
    • ITIH antibody
    • ITIH1 antibody
    • ITIH1_HUMAN antibody
    • Serum-derived hyaluronan-associated protein antibody
    • SHAP antibody
    see all

Images

  • All lanes : Anti-ITIH1/SHAP antibody (ab70048) at 1/500 dilution

    Lane 1 : ITIH1/SHAP transfected 293T cell lysate
    Lane 2 : Non-transfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.

    Secondary
    Lane 1 : Goat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilution
    Lane 2 : Goat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilution

    Predicted band size: 102 kDa
    Observed band size: 102 kDa

References

This product has been referenced in:

  • Ogawa Y  et al. Heavy Chain-Hyaluronan/Pentraxin 3 from Amniotic Membrane Suppresses Inflammation and Scarring in Murine Lacrimal Gland and Conjunctiva of Chronic Graft-versus-Host Disease. Sci Rep 7:42195 (2017). Read more (PubMed: 28165063) »
  • He H  et al. Inhibition of Proliferation and Epithelial Mesenchymal Transition in Retinal Pigment Epithelial Cells by Heavy Chain-Hyaluronan/Pentraxin 3. Sci Rep 7:43736 (2017). Read more (PubMed: 28252047) »
See all 4 Publications for this product

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