Overview

  • Product name

    Anti-ITPA antibody [EPR8779]
    See all ITPA primary antibodies
  • Description

    Rabbit monoclonal [EPR8779] to ITPA
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
    Unsuitable for: Flow Cyt,ICC,IHC-P or IP
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide within Human ITPA aa 1-100 (internal sequence). The exact sequence is proprietary.

  • Positive control

    • Jurkat, HepG2, HeLa and K562 cell lysates; permeabilized HeLa cells.
  • General notes

     

     

     This product was previously labelled as Inosine triphosphate pyrophosphatase

     

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents.

    This product is a recombinant rabbit monoclonal antibody.

Properties

Applications

Our Abpromise guarantee covers the use of ab150420 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Predicted molecular weight: 21 kDa.
  • Application notes
    Is unsuitable for Flow Cyt,ICC,IHC-P or IP.
  • Target

    • Function

      Hydrolyzes ITP and dITP to their respective monophosphate derivatives. Xanthosine 5'-triphosphate (XTP) is also a potential substrate. May be the major enzyme responsible for regulating ITP concentration in cells.
    • Tissue specificity

      Ubiquitous. Highly expressed in heart, liver, sex glands, thyroid and adrenal gland.
    • Involvement in disease

      Defects in ITPA are the cause of inosine triphosphate pyrophosphohydrolase deficiency (ITPA deficiency) [MIM:147520]. It is a common inherited trait characterized by the abnormal accumulation of inosine triphosphate (ITP) in erythrocytes and also leukocytes and fibroblasts. The pathological consequences of ITPA deficiency, if any, are unknown. However, it might have pharmacogenomic implications and be related to increased drug toxicity of purine analog drugs. Three different human populations have been reported with respect to their ITPase activity: high, mean (25% of high) and low activity. The variant Thr-32 is associated with complete loss of enzyme activity, may be by altering the local secondary structure of the protein. Heterozygotes for this polymorphism have 22.5% of the control activity: this is consistent with a dimeric structure of the enzyme.
    • Sequence similarities

      Belongs to the HAM1 NTPase family.
    • Cellular localization

      Cytoplasm.
    • Information by UniProt
    • Database links

    • Alternative names

      • C20orf37 antibody
      • dJ794I6.3 antibody
      • HLC14-06-P antibody
      • Inosine triphosphatase (nucleoside triphosphate pyrophosphatase) antibody
      • Inosine triphosphatase antibody
      • inosine triphosphatase-A antibody
      • Inosine triphosphate pyrophosphatase antibody
      • Inosine triphosphate pyrophosphohydrolase antibody
      • Itpa antibody
      • ITPA_HUMAN antibody
      • ITPase antibody
      • My049 antibody
      • My049 protein antibody
      • Non canonical purine NTP pyrophosphatase antibody
      • Non standard purine NTP pyrophosphatase antibody
      • NTPase antibody
      • nucleoside triphosphate diphosphatase antibody
      • Nucleoside triphosphate pyrophosphatase antibody
      • OK/SW-cl.9 antibody
      • OTTHUMP00000030094 antibody
      • OTTHUMP00000160459 antibody
      • Putative oncogene protein hlc14-06-p antibody
      see all

    Images

    • All lanes : Anti-ITPA antibody [EPR8779] (ab150420) at 1/1000 dilution

      Lane 1 : Jurkat cell lysate
      Lane 2 : HepG2 cell lysate
      Lane 3 : HeLa cell lysate
      Lane 4 : K562 cell lysate

      Lysates/proteins at 10 µg per lane.

      Predicted band size: 21 kDa

    References

    ab150420 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

    There are currently no Customer reviews or Questions for ab150420.
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    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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