Anti-ITPR2 antibody (ab104550)
Key features and details
- Goat polyclonal to ITPR2
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-ITPR2 antibody
See all ITPR2 primary antibodies -
Description
Goat polyclonal to ITPR2 -
Host species
Goat -
Tested applications
Suitable for: IHC-Pmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse, Rat, Cow, Dog -
Immunogen
Synthetic peptide:
C-PIEESNILSPVQD
, corresponding to internal sequence amino acids 1152-1164 of Human ITPR2. -
Positive control
- Human heart, skin and kidney tissues.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
Storage buffer
pH: 7.30
Preservative: 0.02% Sodium azide
Constituents: 0.5% BSA, Tris buffered saline -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab104550 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
---|---|---|
IHC-P |
Use a concentration of 3.75 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
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Notes |
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IHC-P
Use a concentration of 3.75 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
Target
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Function
Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA. -
Tissue specificity
Isoform Short is found in skeletal muscle and heart. -
Involvement in disease
Anhidrosis, isolated, with normal sweat glands -
Sequence similarities
Belongs to the InsP3 receptor family.
Contains 5 MIR domains. -
Domain
The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region. -
Post-translational
modificationsPhosphorylation by cAMP-dependent PKA on Ser-937 increases calcium release. -
Cellular localization
Endoplasmic reticulum membrane. - Information by UniProt
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Database links
- Entrez Gene: 281878 Cow
- Entrez Gene: 3709 Human
- Entrez Gene: 16439 Mouse
- Entrez Gene: 81678 Rat
- Omim: 600144 Human
- SwissProt: Q8WN96 Cow
- SwissProt: Q14571 Human
- SwissProt: Q9Z329 Mouse
see all -
Alternative names
- 4 antibody
- 5-trisphosphate receptor antibody
- Inositol 1 4 5 trisphosphate receptor type 2 antibody
see all
Images
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ab104550 at 3.75µg/ml staining ITPR2 in Human heart by Immunohistochemistry, Formalin-fixed, Paraffin-embedded tissue followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.
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ab104550 at 3.75µg/ml staining ITPR2 in Human skin by Immunohistochemistry, Formalin-fixed, Paraffin-embedded tissue followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.
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ab104550 at 3.75µg/ml staining ITPR2 in Human kidney by Immunohistochemistry, Formalin-fixed, Paraffin-embedded tissue followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.
Datasheets and documents
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Datasheet download
References (0)
ab104550 has not yet been referenced specifically in any publications.