Product nameITPR2 peptide
Our Abpromise guarantee covers the use of ab5842 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Purity> 95 % SDS-PAGE.
This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and ITPR2, catalog ab5805. Using a solution with equal weights per unit volume of peptide and corresponding antibody will yield a solution with a large molar excess of peptide that is able to competitively bind the antibody.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
- 5-trisphosphate receptor
- Inositol 1 4 5 trisphosphate receptor type 2
FunctionReceptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA.
Tissue specificityIsoform Short is found in skeletal muscle and heart.
Involvement in diseaseAnhidrosis, isolated, with normal sweat glands
Sequence similaritiesBelongs to the InsP3 receptor family.
Contains 5 MIR domains.
DomainThe receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.
modificationsPhosphorylation by cAMP-dependent PKA on Ser-937 increases calcium release.
Cellular localizationEndoplasmic reticulum membrane.
- Information by UniProt
ab5842 has not yet been referenced specifically in any publications.