ITPR2 peptide (ab5842)

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Description

  • Product name

    ITPR2 peptide

  • Purity

    > 95 % SDS-PAGE.

  • Animal free

    No

  • Nature

    Synthetic

Associated products

Specifications

Our Abpromise guarantee covers the use of ab5842 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • Form

    Lyophilised

  • Additional notes


    This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and ITPR2, catalog ab5805. Using a solution with equal weights per unit volume of peptide and corresponding antibody will yield a solution with a large molar excess of peptide that is able to competitively bind the antibody.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

  • Reconstitution
    Reconstitute with 0.1 ml of distilled water.

General Info

  • Alternative names

    • 4
    • 5-trisphosphate receptor
    • Inositol 1 4 5 trisphosphate receptor type 2
    • Inositol 1,4,5-trisphosphate receptor type 2
    • Inositol 145 trisphosphate receptor type 2
    • InsP3 R2
    • InsP3R2
    • IP3 R2
    • IP3 receptor
    • IP3 receptor isoform 2
    • IP3R 2
    • IP3R2
    • ITPR 2
    • Itpr2
    • ITPR2_HUMAN
    • Type 2 inositol 1
    • Type 2 inositol 1 4 5 trisphosphate receptor
    • Type 2 inositol 145 trisphosphate receptor
    • Type 2 InsP3 receptor
    see all

  • Function

    Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA.

  • Tissue specificity

    Isoform Short is found in skeletal muscle and heart.

  • Involvement in disease

    Anhidrosis, isolated, with normal sweat glands

  • Sequence similarities

    Belongs to the InsP3 receptor family.
    Contains 5 MIR domains.

  • Domain

    The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.

  • Post-translational
    modifications

    Phosphorylation by cAMP-dependent PKA on Ser-937 increases calcium release.

  • Cellular localization

    Endoplasmic reticulum membrane.
  • Information by UniProt

References

ab5842 has not yet been referenced specifically in any publications.

Publishing research using ab5842? Please let us know so that we can cite the reference in this datasheet.

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