Name: ITPR2 peptide
SKU: ab5842

Our Abpromise guarantee covers the use of ab5842 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Applications

Blocking
Purity

> 95 % SDS-PAGE.
Form

Liquid
Additional notes

This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and ITPR2, catalog ab5805. Using a solution with equal weights per unit volume of peptide and corresponding antibody will yield a solution with a large molar excess of peptide that is able to competitively bind the antibody.
Concentration information loading...

Stability and Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Alternative names
- 4
- 5-trisphosphate receptor
- Inositol 1 4 5 trisphosphate receptor type 2
- Inositol 1,4,5-trisphosphate receptor type 2
- Inositol 145 trisphosphate receptor type 2
- InsP3 R2
- InsP3R2
- IP3 R2
- IP3 receptor
- IP3 receptor isoform 2
- IP3R 2
- IP3R2
- ITPR 2
- Itpr2
- ITPR2_HUMAN
- Type 2 inositol 1
- Type 2 inositol 1 4 5 trisphosphate receptor
- Type 2 inositol 145 trisphosphate receptor
- Type 2 InsP3 receptor
see all
Function

Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA.
Tissue specificity

Isoform Short is found in skeletal muscle and heart.
Involvement in disease

Anhidrosis, isolated, with normal sweat glands
Sequence similarities

Belongs to the InsP3 receptor family.
Contains 5 MIR domains.
Domain

The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.
Post-translational
modifications

Phosphorylation by cAMP-dependent PKA on Ser-937 increases calcium release.
Cellular localization

Endoplasmic reticulum membrane.
Target information above from: UniProt accession Q14571 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt

ab5842 has not yet been referenced specifically in any publications.

Publishing research using ab5842? Please let us know so that we can cite the reference in this datasheet.

Customer reviews and Q&As

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

ITPR2 peptide (ab5842)