The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and ITPR2, catalog ab5805. Using a solution with equal weights per unit volume of peptide and corresponding antibody will yield a solution with a large molar excess of peptide that is able to competitively bind the antibody.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Inositol 1 4 5 trisphosphate receptor type 2
Inositol 1,4,5-trisphosphate receptor type 2
Inositol 145 trisphosphate receptor type 2
IP3 receptor isoform 2
Type 2 inositol 1
Type 2 inositol 1 4 5 trisphosphate receptor
Type 2 inositol 145 trisphosphate receptor
Type 2 InsP3 receptor
Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA.
Isoform Short is found in skeletal muscle and heart.
Involvement in disease
Anhidrosis, isolated, with normal sweat glands
Belongs to the InsP3 receptor family. Contains 5 MIR domains.
The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.
Phosphorylation by cAMP-dependent PKA on Ser-937 increases calcium release.