Overview

  • Product name
    ITPR2 peptide

Description

  • Nature
    Synthetic

Associated products

Specifications

Our Abpromise guarantee covers the use of ab5842 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • Purity
    > 95 % SDS-PAGE.

  • Form
    Liquid
  • Additional notes


    This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and ITPR2, catalog ab5805. Using a solution with equal weights per unit volume of peptide and corresponding antibody will yield a solution with a large molar excess of peptide that is able to competitively bind the antibody.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

General Info

  • Alternative names
    • 4
    • 5-trisphosphate receptor
    • Inositol 1 4 5 trisphosphate receptor type 2
    • Inositol 1,4,5-trisphosphate receptor type 2
    • Inositol 145 trisphosphate receptor type 2
    • InsP3 R2
    • InsP3R2
    • IP3 R2
    • IP3 receptor
    • IP3 receptor isoform 2
    • IP3R 2
    • IP3R2
    • ITPR 2
    • Itpr2
    • ITPR2_HUMAN
    • Type 2 inositol 1
    • Type 2 inositol 1 4 5 trisphosphate receptor
    • Type 2 inositol 145 trisphosphate receptor
    • Type 2 InsP3 receptor
    see all
  • Function
    Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA.
  • Tissue specificity
    Isoform Short is found in skeletal muscle and heart.
  • Involvement in disease
    Anhidrosis, isolated, with normal sweat glands
  • Sequence similarities
    Belongs to the InsP3 receptor family.
    Contains 5 MIR domains.
  • Domain
    The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.
  • Post-translational
    modifications
    Phosphorylation by cAMP-dependent PKA on Ser-937 increases calcium release.
  • Cellular localization
    Endoplasmic reticulum membrane.
  • Information by UniProt

References

ab5842 has not yet been referenced specifically in any publications.

Publishing research using ab5842? Please let us know so that we can cite the reference in this datasheet.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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