ITPR2 peptide (ab5842)
- Datasheet
- References
- Protocols
Overview
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Product nameITPR2 peptide
Description
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NatureSynthetic
Associated products
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Positive Controls
Specifications
Our Abpromise guarantee covers the use of ab5842 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Applications
Blocking
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Purity> 95 % SDS-PAGE.
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FormLiquid
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Additional notes
This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and ITPR2, catalog ab5805. Using a solution with equal weights per unit volume of peptide and corresponding antibody will yield a solution with a large molar excess of peptide that is able to competitively bind the antibody.
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Concentration information loading...
Preparation and Storage
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Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
General Info
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Alternative names
- 4
- 5-trisphosphate receptor
- Inositol 1 4 5 trisphosphate receptor type 2
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FunctionReceptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA.
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Tissue specificityIsoform Short is found in skeletal muscle and heart.
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Involvement in diseaseAnhidrosis, isolated, with normal sweat glands
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Sequence similaritiesBelongs to the InsP3 receptor family.
Contains 5 MIR domains. -
DomainThe receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.
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Post-translational
modificationsPhosphorylation by cAMP-dependent PKA on Ser-937 increases calcium release. -
Cellular localizationEndoplasmic reticulum membrane.
- Information by UniProt
Datasheets and documents
References
ab5842 has not yet been referenced specifically in any publications.