Key features and details
- Rabbit polyclonal to ITPR3
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Product nameAnti-ITPR3 antibody
See all ITPR3 primary antibodies
DescriptionRabbit polyclonal to ITPR3
Tested applicationsSuitable for: IHC-Pmore details
Species reactivityReacts with: Human
Predicted to work with: Guinea pig, Gorilla, Orangutan
Synthetic peptide corresponding to a region within amino acids 625-675 of Human ITPR3 (NP_002215.2).
- Human Breast Carcinoma, Colon Carcinoma, Osteosarcoma, Ovarian Carcinoma, and Stomach Adenocarcinoma tissues
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Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.
We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.
In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
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Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage bufferpH: 6.8
Preservative: 0.09% Sodium azide
Constituents: 99% Tris buffered saline, 0.1% BSA
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab113292 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||1/100 - 1/500. Epitope exposure is recommended. Epitope exposure with citrate buffer will enhance staining.|
FunctionReceptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.
Tissue specificityExpressed in intestinal crypt and villus epithelial cells.
Sequence similaritiesBelongs to the InsP3 receptor family.
Contains 5 MIR domains.
DomainThe receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.
modificationsPhosphorylated on tyrosine residues. Phosphorylated by AKT1 on serine and/or threonine residues.
Cellular localizationEndoplasmic reticulum membrane.
- Information by UniProt
- 4 antibody
- 5-trisphosphate receptor antibody
- 5-trisphosphate receptor type 3 antibody
ab113292, at 1/250 dilution, staining ITPR3 in formalin-fixed, paraffin-embedded Human stomach carcinoma by Immunohistochemistry with DAB staining.
ab113292, at 1/250 dilution, staining ITPR3 in formalin-fixed, paraffin-embedded Human stomach carcinoma by Immunohistochemistry. Detection: Red-fluorescent Goat anti-Rabbit IgG-heavy and light chain cross-adsorbed Antibody DyLight® 594 Conjugated used at a dilution of 1/100.
ab113292 has been referenced in 1 publication.
- Causton B et al. CARMA3 Mediates Allergic Lung Inflammation in Response to Alternaria alternata. Am J Respir Cell Mol Biol 59:684-694 (2018). PubMed: 29958012