Key features and details
- Rabbit polyclonal to ITPR3
- Suitable for: WB, ELISA
- Reacts with: Recombinant fragment
- Isotype: IgG
Product nameAnti-ITPR3 antibody
See all ITPR3 primary antibodies
DescriptionRabbit polyclonal to ITPR3
Tested applicationsSuitable for: WB, ELISAmore details
Species reactivityReacts with: Recombinant fragment
Predicted to work with: Mouse, Rat, Human
Synthetic peptide (Human) corresponding to a C terminal sequence.
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage bufferpH: 7.2
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), PBS
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab55983 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||Use a concentration of 1 µg/ml. Predicted molecular weight: 304 kDa. This antibody has been tested in Western blot against the recombinant peptide used as an immunogen. We have no data on detection of endogenous protein.|
|ELISA||Use at an assay dependent dilution.|
FunctionReceptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.
Tissue specificityExpressed in intestinal crypt and villus epithelial cells.
Sequence similaritiesBelongs to the InsP3 receptor family.
Contains 5 MIR domains.
DomainThe receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.
modificationsPhosphorylated on tyrosine residues. Phosphorylated by AKT1 on serine and/or threonine residues.
Cellular localizationEndoplasmic reticulum membrane.
- Information by UniProt
- 4 antibody
- 5-trisphosphate receptor antibody
- 5-trisphosphate receptor type 3 antibody
ab55983 has been referenced in 2 publications.
- Rezuchova I et al. Type 3 inositol 1,4,5-trisphosphate receptor has antiapoptotic and proliferative role in cancer cells. Cell Death Dis 10:186 (2019). PubMed: 30796197
- Kang S et al. Trifluoperazine, a Well-Known Antipsychotic, Inhibits Glioblastoma Invasion by Binding to Calmodulin and Disinhibiting Calcium Release Channel IP3R. Mol Cancer Ther 16:217-227 (2017). PubMed: 28062709