Overview

  • Product name

    ITSA-1, HDAC activator
  • Description

    Cell-permeable HDAC activator. Selective Trichostatin A suppressor.
  • Biological description

    Cell-permeable HDAC activator. Selective Trichostatin A (ab120850) suppressor. Counteracts Trichostatin A-induced cell cycle arrest. Inhibits Trichostatin A-induced tubulin acetylation. Shows no effect on the activity of other HDAC inhibitors.
  • Purity

    > 98%
  • CAS Number

    200626-61-5
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    Benzotriazol-1-yl-(2,4-dichlorophenyl)methanone
  • Molecular weight

    292.12
  • Molecular formula

    C13H7Cl2N3O
  • PubChem identifier

    771910
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 75 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1=CC=C2C(=C1)N=NN2C(=O)C3=C(C=C(C=C3)Cl)Cl
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Koeller KM  et al. Chemical genetic modifier screens: small molecule trichostatin suppressors as probes of intracellular histone and tubulin acetylation. Chem Biol 10:397-410 (2003). Read more (PubMed: 12770822) »
  • Haggarty SJ  et al. Small molecule modulation of the human chromatid decatenation checkpoint. Chem Biol 10:1267-79 (2003). Read more (PubMed: 14700634) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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