Ivermectin, Positive allosteric modulator of alpha7 nicotinic acetylcholine receptors (ab141813)

Overview

  • Product name

    Ivermectin, Positive allosteric modulator of alpha7 nicotinic acetylcholine receptors
  • Description

    Positive allosteric modulator of α7 nicotinic acetylcholine receptors
  • Biological description

    Positive allosteric modulator of α7 neuronal nicotinic acetylcholine receptor. Allosteric effector of P2X4 receptors. Antihelmintic. Modulates glutamate- and GABA-activated chloride channels. Potentiates glycine-gated currents at low concentrations (30 nM).
  • Purity

    > 96%
  • CAS Number

    70288-86-7
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    22,23-Dihydroavermectin B1a
  • Molecular weight

    875.09
  • Molecular formula

    C48H74O14
  • PubChem identifier

    6440492
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 50 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CCC(C)C1C(CCC2(O1)CC3CC(O2)CC=C(C(C(C=CC=C4COC5C4(C(C=C(C5O)C)C(=O)O3)O)C)OC6CC(C(C(O6)C)OC7CC(C(C(O7)C)O)OC)OC)C)C
  • Source

    Synthetic

  • Research areas

Images

  • Ivermectin activates a7 nicotinic AChR heterologously expressed in Xenopus oocytes.

    Current traces of a7 nicotinic AChR at -80mV holding potential. Currents were elicited by applications 10 µM acetylcholine every 50 seconds. Increases of these induced currents were achieved upon perfusion of 10 µM Ivermectin (ab141813), as indicated by the horizontal bar.

References

This product has been referenced in:

  • Campbell WC History of avermectin and ivermectin, with notes on the history of other macrocyclic lactone antiparasitic agents. Curr Pharm Biotechnol 13:853-65 (2012). Read more (PubMed: 22039784) »
  • Shan Q  et al. Ivermectin, an unconventional agonist of the glycine receptor chloride channel. J Biol Chem 276:12556-64 (2001). Read more (PubMed: 11278873) »
  • Krause RM  et al. Ivermectin: a positive allosteric effector of the alpha7 neuronal nicotinic acetylcholine receptor. Mol Pharmacol 53:283-94 (1998). Read more (PubMed: 9463487) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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