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IWP-4 (ab278076)

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Key features and details

  • Potent inhibitor of Wnt
  • CAS Number: 686772-17-8
  • Purity: > 98%

  • Soluble in DMSO to 1 mM

  • Form / State: Solid
  • Source: Synthetic

Overview

  • Product name

    IWP-4

  • Description

    Potent inhibitor of Wnt

  • Biological description

    Potent inhibitor of Wnt pathway regulatory protein porupine (Porcn). Blocks Wnt protein secretion and prevents the canonical and non-canonical signaling pathways. Blocks palmitylation, and subsquent secretion and activity of Wnt. Induces differentiation of cardiomyocytes from human ESCs and iPSCs.

  • Purity

    > 98%

  • General notes

    For obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.

  • CAS Number

    686772-17-8

  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    N-(6-Methyl-2-benzothiazolyl)-2-[[3,4,6,7-tetrahydro-3-(2-methoxyphenyl)-4- oxothieno[3,2-d]pyrimidin-2-yl]thio]acetamide

  • Molecular weight

    496.62

  • Molecular formula

    C23H20N4O3S3

  • PubChem identifier

    2155264

  • Storage instructions

    Shipped at room temperature. Store at -20°C.

  • Solubility overview

    Soluble in DMSO to 1 mM

  • Handling

    Refer to SDS for further information.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC1=CC2=C(C=C1)N=C(S2)NC(=O)CSC3=NC4=C(C(=O)N3C5=CC=CC=C5OC)SCC4

  • Source

    Synthetic

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

References (3)

Publishing research using ab278076? Please let us know so that we can cite the reference in this datasheet.

ab278076 has been referenced in 3 publications.

  • Narytnyk A  et al. Differentiation of human epidermal neural crest stem cells (hEPI-NCSC) into virtually homogenous populations of dopaminergic neurons. Stem Cell Rev Rep 10:316-26 (2014). PubMed: 24399192
  • Frith JE  et al. Microbioreactor array screening of Wnt modulators and microenvironmental factors in osteogenic differentiation of mesenchymal progenitor cells. PLoS One 8:e82931 (2013). PubMed: 24376608
  • Lian X  et al. Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling. Proc Natl Acad Sci U S A 109:E1848-57 (2012). PubMed: 22645348

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