Recombinant Anti-JAK2 (phospho Y1007 + Y1008) antibody [E132] (ab32101)

Rabbit recombinant monoclonal JAK2 (phospho Y1007 + Y1008) antibody [E132]. Validated in WB, IP, ELISA, IHC, Flow Cyt, Dot, ICC/IF and tested in Mouse, Rat, Human. Cited in 41 publication(s).

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ab32101 has been referenced in 42 publications.

  • Chen Z  et al. Long non-coding RNA XIST promotes the development of esophageal cancer by sponging miR-494 to regulate CDK6 expression. Biomed Pharmacother 109:2228-2236 (2019). PubMed: 30551480
  • Sun H  et al. Long noncoding RNA C2dat1 protects H9c2 cells against hypoxia injury by downregulating miR-22. J Cell Physiol N/A:N/A (2019). PubMed: 31004350
  • Zhang S  et al. Swiprosin-1 deficiency impairs macrophage immune response of septic mice. JCI Insight 3:N/A (2018). PubMed: 29415882
  • Li D  et al. Eriodictyol Attenuates Myocardial Ischemia-Reperfusion Injury through the Activation of JAK2. Front Pharmacol 9:33 (2018). PubMed: 29441020
  • Yoshikawa T  et al. JAK2/STAT3 pathway as a therapeutic target in ovarian cancers. Oncol Lett 15:5772-5780 (2018). IHC ; Human . PubMed: 29545902
  • Liu S  et al. Protective effects of N(2)-L-alanyl-L-glutamine mediated by the JAK2/STAT3 signaling pathway on myocardial ischemia reperfusion. Mol Med Rep 17:5102-5108 (2018). PubMed: 29393473
  • Li N  et al. Downregulation of SIRT6 by miR-34c-5p is associated with poor prognosis and promotes colon cancer proliferation through inhibiting apoptosis via the JAK2/STAT3 signaling pathway. Int J Oncol N/A:N/A (2018). PubMed: 29512698
  • Chen L  et al. Effects of purified Omphalia lapidescens protein on metastasis, cell cycle, apoptosis and the JAK-STAT signaling pathway in SGC-7901 human gastric cells. Oncol Lett 15:4161-4170 (2018). PubMed: 29541181
  • Yin L  et al. Manganese exposure facilitates microglial JAK2-STAT3 signaling and consequent secretion of TNF-a and IL-1ß to promote neuronal death. Neurotoxicology 64:195-203 (2018). WB . PubMed: 28385490
  • Wang X  et al. Sarcodon imbricatus polysaccharides improve mouse hematopoietic function after cyclophosphamide-induced damage via G-CSF mediated JAK2/STAT3 pathway. Cell Death Dis 9:578 (2018). PubMed: 29784961
  • Chen K  et al. Hydrogen-rich solution attenuates myocardial injury caused by cardiopulmonary bypass in rats via the Janus-activated kinase 2/signal transducer and activator of transcription 3 signaling pathway. Oncol Lett 16:167-178 (2018). PubMed: 29928398
  • Zhang K  et al. The SHH/Gli axis regulates CD90-mediated liver cancer stem cell function by activating the IL6/JAK2 pathway. J Cell Mol Med 22:3679-3690 (2018). PubMed: 29722127
  • Yang F  et al. IRE1a aggravates ischemia reperfusion injury of fatty liver by regulating phenotypic transformation of kupffer cells. Free Radic Biol Med 124:395-407 (2018). PubMed: 29969718
  • Liu X  et al. MicroRNA-204 deregulation in lung adenocarcinoma controls the biological behaviors of endothelial cells potentially by modulating Janus kinase 2-signal transducer and activator of transcription 3 pathway. IUBMB Life 70:81-91 (2018). PubMed: 29281186
  • Song Q  et al. JAK/STAT3 and Smad3 activities are required for the wound healing properties of Periplaneta americana extracts. Int J Mol Med 40:465-473 (2017). WB, IHC-P . PubMed: 28656220
  • Wang D  et al. Maslinic acid suppresses the growth of human gastric cells by inducing apoptosis via inhibition of the interleukin-6 mediated Janus kinase/signal transducer and activator of transcription 3 signaling pathway. Oncol Lett 13:4875-4881 (2017). PubMed: 28599489
  • Gan L  et al. Reduced Endoplasmic Reticulum Stress-Mediated Autophagy Is Required for Leptin Alleviating Inflammation in Adipose Tissue. Front Immunol 8:1507 (2017). PubMed: 29250056
  • Shintani T  et al. PTPRJ Inhibits Leptin Signaling, and Induction of PTPRJ in the Hypothalamus Is a Cause of the Development of Leptin Resistance. Sci Rep 7:11627 (2017). WB . PubMed: 28912580
  • Chen Y  et al. Dexmedetomidine reduces the neuronal apoptosis related to cardiopulmonary bypass by inhibiting activation of the JAK2-STAT3 pathway. Drug Des Devel Ther 11:2787-2799 (2017). PubMed: 29033541
  • Lu W  et al. Calf Spleen Extractive Injection protects mice against cyclophosphamide-induced hematopoietic injury through G-CSF-mediated JAK2/STAT3 signaling. Sci Rep 7:8402 (2017). PubMed: 28827748
  • Luo LN  et al. Osthole decreases renal ischemia-reperfusion injury by suppressing JAK2/STAT3 signaling activation. Exp Ther Med 12:2009-2014 (2016). WB ; Rat . PubMed: 27698686
  • Alves de Medeiros AK  et al. JAK3 as an Emerging Target for Topical Treatment of Inflammatory Skin Diseases. PLoS One 11:e0164080 (2016). IHC ; Human . PubMed: 27711196
  • Liu Z  et al. Overexpression of variant PNPLA3 gene at I148M position causes malignant transformation of hepatocytes via IL-6-JAK2/STAT3 pathway in low dose free fatty acid exposure: a laboratory investigation in vitro and in vivo. Am J Transl Res 8:1319-38 (2016). PubMed: 27186262
  • Wu M  et al. The C-terminal tail of polycystin-1 regulates complement factor B expression by signal transducer and activator of transcription 1. Am J Physiol Renal Physiol 310:F1284-94 (2016). PubMed: 26984954
  • Yang C  et al. Musashi-2 promotes migration and invasion in bladder cancer via activation of the JAK2/STAT3 pathway. Lab Invest 96:950-8 (2016). PubMed: 27322953
  • Zhang Y  et al. Inhibition of casein kinase II reduces TGFß induced fibroblast activation and ameliorates experimental fibrosis. Ann Rheum Dis N/A:N/A (2014). PubMed: 24431397
  • Sedek M  et al. Multimeric growth hormone receptor complexes serve as signaling platforms. J Biol Chem 289:65-73 (2014). PubMed: 24280222
  • Liu W  et al. Epigallocatechin-3-gallate ameliorates seawater aspiration-induced acute lung injury via regulating inflammatory cytokines and inhibiting JAK/STAT1 pathway in rats. Mediators Inflamm 2014:612593 (2014). WB ; Rat . PubMed: 24692852
  • Gallipoli P  et al. JAK2/STAT5 inhibition by nilotinib with ruxolitinib contributes to the elimination of CML CD34+ cells in vitro and in vivo. Blood 124:1492-501 (2014). WB, Flow Cyt ; Mouse . PubMed: 24957147
  • Wu Q  et al. Crosstalk of JNK1-STAT3 is critical for RAW264.7 cell survival. Cell Signal 26:2951-60 (2014). Mouse . PubMed: 25269780
  • Yang JM  et al. Angiotensin-(1-7) dose-dependently inhibits atherosclerotic lesion formation and enhances plaque stability by targeting vascular cells. Arterioscler Thromb Vasc Biol 33:1978-85 (2013). WB ; Mouse . PubMed: 23723368
  • Fiskus W  et al. Dual PI3K/AKT/mTOR inhibitor BEZ235 synergistically enhances the activity of JAK2 inhibitor against cultured and primary human myeloproliferative neoplasm cells. Mol Cancer Ther 12:577-88 (2013). PubMed: 23445613
  • Chen CC  et al. Gene expression profiling for analysis acquired oxaliplatin resistant factors in human gastric carcinoma TSGH-S3 cells: the role of IL-6 signaling and Nrf2/AKR1C axis identification. Biochem Pharmacol 86:872-87 (2013). Human . PubMed: 23933386
  • Neviani P  et al. PP2A-activating drugs selectively eradicate TKI-resistant chronic myeloid leukemic stem cells. J Clin Invest 123:4144-57 (2013). PubMed: 23999433
  • Bao W  et al. A TrkB-STAT3-miR-204-5p regulatory circuitry controls proliferation and invasion of endometrial carcinoma cells. Mol Cancer 12:155 (2013). WB ; Human . PubMed: 24321270
  • Byrne R  et al. A dynamic real time in vivo and static ex vivo analysis of granulomonocytic cell migration in the collagen-induced arthritis model. PLoS One 7:e35194 (2012). IHC-P ; Mouse . PubMed: 22529989
  • Kirabo A  et al. Vascular smooth muscle Jak2 deletion prevents angiotensin II-mediated neointima formation following injury in mice. J Mol Cell Cardiol 50:1026-34 (2011). IHC-Fr ; Mouse . PubMed: 21420414
  • Fiskus W  et al. Heat Shock Protein 90 Inhibitor Is Synergistic with JAK2 Inhibitor and Overcomes Resistance to JAK2-TKI in Human Myeloproliferative Neoplasm Cells. Clin Cancer Res 17:7347-58 (2011). WB ; Human . PubMed: 21976548
  • Kirabo A  et al. The Jak2 Inhibitor, G6, Alleviates Jak2-V617F-Mediated Myeloproliferative Neoplasia by Providing Significant Therapeutic Efficacy to the Bone Marrow. Neoplasia 13:1058-68 (2011). IHC-P ; Mouse . PubMed: 22131881
  • Lin MH  et al. Epidermal hyperproliferation in mice lacking fatty acid transport protein 4 (FATP4) involves ectopic EGF receptor and STAT3 signaling. Dev Biol 344:707-19 (2010). IHC-P ; Mouse . PubMed: 20513444
  • Dawson MA  et al. JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin. Nature 461:819-22 (2009). WB ; Human . PubMed: 19783980
  • Devi YS  et al. Regulation of transcription factors and repression of Sp1 by prolactin signaling through the short isoform of its cognate receptor. Endocrinology 150:3327-35 (2009). WB ; Rat . PubMed: 19342455

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