Recombinant
RabMAb

Recombinant Anti-JAK2 (phospho Y1007 + Y1008) antibody [E132] (ab32101)

Rabbit recombinant monoclonal JAK2 (phospho Y1007 + Y1008) antibody [E132]. Validated in WB, IP, ELISA, IHC, Flow Cyt, Dot, ICC/IF and tested in Mouse, Rat, Human. Cited in 41 publication(s).

Publishing research using ab32101? Please let us know so that we can cite the reference in this datasheet.

ab32101 has been referenced in 42 publications.

  • Chen Z  et al. Long non-coding RNA XIST promotes the development of esophageal cancer by sponging miR-494 to regulate CDK6 expression. Biomed Pharmacother 109:2228-2236 (2019). PubMed: 30551480
  • Sun H  et al. Long noncoding RNA C2dat1 protects H9c2 cells against hypoxia injury by downregulating miR-22. J Cell Physiol N/A:N/A (2019). PubMed: 31004350
  • Zhang S  et al. Swiprosin-1 deficiency impairs macrophage immune response of septic mice. JCI Insight 3:N/A (2018). PubMed: 29415882
  • Li D  et al. Eriodictyol Attenuates Myocardial Ischemia-Reperfusion Injury through the Activation of JAK2. Front Pharmacol 9:33 (2018). PubMed: 29441020
  • Yoshikawa T  et al. JAK2/STAT3 pathway as a therapeutic target in ovarian cancers. Oncol Lett 15:5772-5780 (2018). IHC ; Human . PubMed: 29545902
  • Liu S  et al. Protective effects of N(2)-L-alanyl-L-glutamine mediated by the JAK2/STAT3 signaling pathway on myocardial ischemia reperfusion. Mol Med Rep 17:5102-5108 (2018). PubMed: 29393473
  • Li N  et al. Downregulation of SIRT6 by miR-34c-5p is associated with poor prognosis and promotes colon cancer proliferation through inhibiting apoptosis via the JAK2/STAT3 signaling pathway. Int J Oncol N/A:N/A (2018). PubMed: 29512698
  • Chen L  et al. Effects of purified Omphalia lapidescens protein on metastasis, cell cycle, apoptosis and the JAK-STAT signaling pathway in SGC-7901 human gastric cells. Oncol Lett 15:4161-4170 (2018). PubMed: 29541181
  • Yin L  et al. Manganese exposure facilitates microglial JAK2-STAT3 signaling and consequent secretion of TNF-a and IL-1ß to promote neuronal death. Neurotoxicology 64:195-203 (2018). WB . PubMed: 28385490
  • Wang X  et al. Sarcodon imbricatus polysaccharides improve mouse hematopoietic function after cyclophosphamide-induced damage via G-CSF mediated JAK2/STAT3 pathway. Cell Death Dis 9:578 (2018). PubMed: 29784961
  • Chen K  et al. Hydrogen-rich solution attenuates myocardial injury caused by cardiopulmonary bypass in rats via the Janus-activated kinase 2/signal transducer and activator of transcription 3 signaling pathway. Oncol Lett 16:167-178 (2018). PubMed: 29928398
  • Zhang K  et al. The SHH/Gli axis regulates CD90-mediated liver cancer stem cell function by activating the IL6/JAK2 pathway. J Cell Mol Med 22:3679-3690 (2018). PubMed: 29722127
  • Yang F  et al. IRE1a aggravates ischemia reperfusion injury of fatty liver by regulating phenotypic transformation of kupffer cells. Free Radic Biol Med 124:395-407 (2018). PubMed: 29969718
  • Liu X  et al. MicroRNA-204 deregulation in lung adenocarcinoma controls the biological behaviors of endothelial cells potentially by modulating Janus kinase 2-signal transducer and activator of transcription 3 pathway. IUBMB Life 70:81-91 (2018). PubMed: 29281186
  • Song Q  et al. JAK/STAT3 and Smad3 activities are required for the wound healing properties of Periplaneta americana extracts. Int J Mol Med 40:465-473 (2017). WB, IHC-P . PubMed: 28656220
  • Wang D  et al. Maslinic acid suppresses the growth of human gastric cells by inducing apoptosis via inhibition of the interleukin-6 mediated Janus kinase/signal transducer and activator of transcription 3 signaling pathway. Oncol Lett 13:4875-4881 (2017). PubMed: 28599489
  • Gan L  et al. Reduced Endoplasmic Reticulum Stress-Mediated Autophagy Is Required for Leptin Alleviating Inflammation in Adipose Tissue. Front Immunol 8:1507 (2017). PubMed: 29250056
  • Shintani T  et al. PTPRJ Inhibits Leptin Signaling, and Induction of PTPRJ in the Hypothalamus Is a Cause of the Development of Leptin Resistance. Sci Rep 7:11627 (2017). WB . PubMed: 28912580
  • Chen Y  et al. Dexmedetomidine reduces the neuronal apoptosis related to cardiopulmonary bypass by inhibiting activation of the JAK2-STAT3 pathway. Drug Des Devel Ther 11:2787-2799 (2017). PubMed: 29033541
  • Lu W  et al. Calf Spleen Extractive Injection protects mice against cyclophosphamide-induced hematopoietic injury through G-CSF-mediated JAK2/STAT3 signaling. Sci Rep 7:8402 (2017). PubMed: 28827748
  • Luo LN  et al. Osthole decreases renal ischemia-reperfusion injury by suppressing JAK2/STAT3 signaling activation. Exp Ther Med 12:2009-2014 (2016). WB ; Rat . PubMed: 27698686
  • Alves de Medeiros AK  et al. JAK3 as an Emerging Target for Topical Treatment of Inflammatory Skin Diseases. PLoS One 11:e0164080 (2016). IHC ; Human . PubMed: 27711196
  • Liu Z  et al. Overexpression of variant PNPLA3 gene at I148M position causes malignant transformation of hepatocytes via IL-6-JAK2/STAT3 pathway in low dose free fatty acid exposure: a laboratory investigation in vitro and in vivo. Am J Transl Res 8:1319-38 (2016). PubMed: 27186262
  • Wu M  et al. The C-terminal tail of polycystin-1 regulates complement factor B expression by signal transducer and activator of transcription 1. Am J Physiol Renal Physiol 310:F1284-94 (2016). PubMed: 26984954
  • Yang C  et al. Musashi-2 promotes migration and invasion in bladder cancer via activation of the JAK2/STAT3 pathway. Lab Invest 96:950-8 (2016). PubMed: 27322953
  • Zhang Y  et al. Inhibition of casein kinase II reduces TGFß induced fibroblast activation and ameliorates experimental fibrosis. Ann Rheum Dis N/A:N/A (2014). PubMed: 24431397
  • Sedek M  et al. Multimeric growth hormone receptor complexes serve as signaling platforms. J Biol Chem 289:65-73 (2014). PubMed: 24280222
  • Liu W  et al. Epigallocatechin-3-gallate ameliorates seawater aspiration-induced acute lung injury via regulating inflammatory cytokines and inhibiting JAK/STAT1 pathway in rats. Mediators Inflamm 2014:612593 (2014). WB ; Rat . PubMed: 24692852
  • Gallipoli P  et al. JAK2/STAT5 inhibition by nilotinib with ruxolitinib contributes to the elimination of CML CD34+ cells in vitro and in vivo. Blood 124:1492-501 (2014). WB, Flow Cyt ; Mouse . PubMed: 24957147
  • Wu Q  et al. Crosstalk of JNK1-STAT3 is critical for RAW264.7 cell survival. Cell Signal 26:2951-60 (2014). Mouse . PubMed: 25269780
  • Yang JM  et al. Angiotensin-(1-7) dose-dependently inhibits atherosclerotic lesion formation and enhances plaque stability by targeting vascular cells. Arterioscler Thromb Vasc Biol 33:1978-85 (2013). WB ; Mouse . PubMed: 23723368
  • Fiskus W  et al. Dual PI3K/AKT/mTOR inhibitor BEZ235 synergistically enhances the activity of JAK2 inhibitor against cultured and primary human myeloproliferative neoplasm cells. Mol Cancer Ther 12:577-88 (2013). PubMed: 23445613
  • Chen CC  et al. Gene expression profiling for analysis acquired oxaliplatin resistant factors in human gastric carcinoma TSGH-S3 cells: the role of IL-6 signaling and Nrf2/AKR1C axis identification. Biochem Pharmacol 86:872-87 (2013). Human . PubMed: 23933386
  • Neviani P  et al. PP2A-activating drugs selectively eradicate TKI-resistant chronic myeloid leukemic stem cells. J Clin Invest 123:4144-57 (2013). PubMed: 23999433
  • Bao W  et al. A TrkB-STAT3-miR-204-5p regulatory circuitry controls proliferation and invasion of endometrial carcinoma cells. Mol Cancer 12:155 (2013). WB ; Human . PubMed: 24321270
  • Byrne R  et al. A dynamic real time in vivo and static ex vivo analysis of granulomonocytic cell migration in the collagen-induced arthritis model. PLoS One 7:e35194 (2012). IHC-P ; Mouse . PubMed: 22529989
  • Kirabo A  et al. Vascular smooth muscle Jak2 deletion prevents angiotensin II-mediated neointima formation following injury in mice. J Mol Cell Cardiol 50:1026-34 (2011). IHC-Fr ; Mouse . PubMed: 21420414
  • Fiskus W  et al. Heat Shock Protein 90 Inhibitor Is Synergistic with JAK2 Inhibitor and Overcomes Resistance to JAK2-TKI in Human Myeloproliferative Neoplasm Cells. Clin Cancer Res 17:7347-58 (2011). WB ; Human . PubMed: 21976548
  • Kirabo A  et al. The Jak2 Inhibitor, G6, Alleviates Jak2-V617F-Mediated Myeloproliferative Neoplasia by Providing Significant Therapeutic Efficacy to the Bone Marrow. Neoplasia 13:1058-68 (2011). IHC-P ; Mouse . PubMed: 22131881
  • Lin MH  et al. Epidermal hyperproliferation in mice lacking fatty acid transport protein 4 (FATP4) involves ectopic EGF receptor and STAT3 signaling. Dev Biol 344:707-19 (2010). IHC-P ; Mouse . PubMed: 20513444
  • Dawson MA  et al. JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin. Nature 461:819-22 (2009). WB ; Human . PubMed: 19783980
  • Devi YS  et al. Regulation of transcription factors and repression of Sp1 by prolactin signaling through the short isoform of its cognate receptor. Endocrinology 150:3327-35 (2009). WB ; Rat . PubMed: 19342455

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