Key features and details
- Rat monoclonal [19 H36] to JAM-C
- Suitable for: IP, Flow Cyt, IHC-Fr
- Reacts with: Mouse, Human
- Isotype: IgG2a
Product nameAnti-JAM-C antibody [19 H36]
See all JAM-C primary antibodies
DescriptionRat monoclonal [19 H36] to JAM-C
Tested applicationsSuitable for: IP, Flow Cyt, IHC-Frmore details
Unsuitable for: IHC-P or WB
Species reactivityReacts with: Mouse, Human
This information is considered to be commercially sensitive.
- High endothelial venules of lymphoid organs, lymphoendothelial cells and endothelial cells of the kidney
Previously labelled as Junctional Adhesion Molecule C.
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage bufferPreservative: 0.02% Sodium azide
Constituents: PBS, 0.1% BSA
Concentration information loading...
PurityProtein G purified
Clone number19 H36
Our Abpromise guarantee covers the use of ab16889 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IP||Use at an assay dependent concentration.|
|Flow Cyt||Use at an assay dependent concentration.
ab18450 - Rat monoclonal IgG2a, is suitable for use as an isotype control with this antibody.
|IHC-Fr||Use at an assay dependent concentration.|
FunctionParticipates in cell-cell adhesion. It is a counterreceptor for ITGAM, mediating leukocyte-platelet interactions and is involved in the regulation of transepithelial migration of polymorphonuclear neutrophils (PMN). The soluble form is a mediator of angiogenesis.
Tissue specificityHighest expression in placenta, brain and kidney. Significant expression is detected on platelets. Expressed in intestinal mucosa cells. Expressed in the vascular endothelium. Found in serum (at protein level). Also detected in the synovial fluid of patients with rheumatoid arthritis, psoriatic arthritis or ostearthritis (at protein level).
Involvement in diseaseDefects in JAM3 are the cause of hemorrhagic destruction of the brain with subependymal calcification and cataracts (HDBSCC) [MIM:613730]. A syndrome characterized by congenital cataracts and severe brain abnormalities apparently resulting from hemorrhagic destruction of the brain tissue, including the cerebral white matter and basal ganglia. Patients manifest profound developmental delay, and other neurologic features included seizures, spasticity, and hyperreflexia. Brain imaging shows multifocal intraparenchymal hemorrhage with associated liquefaction and massive cystic degeneration, and calcification in the subependymal region and in brain tissue.
Sequence similaritiesBelongs to the immunoglobulin superfamily.
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Contains 1 Ig-like V-type (immunoglobulin-like) domain.
modificationsProteolytically cleaved from endothelial cells surface into a soluble form by ADAM10 and ADAM17; the release of soluble JAM3 is increased by proinflammatory factors.
Cellular localizationCell membrane. Cell junction > desmosome. Secreted > extracellular space. In epithelial cells, it is expressed at desmosomes but not at tight junctions. Localizes at the cell surface of endothelial cells; treatment of endothelial cells with vascular endothelial growth factor stimulates recruitement of JAM3 to cell-cell contacts.
- Information by UniProt
- FLJ14529 antibody
- JAM 2 antibody
- JAM 3 antibody
ab16889 has not yet been referenced specifically in any publications.