Jasplakinolide, Actin polymerization and stabilization inducer (ab141409)

Overview

  • Product name
    Jasplakinolide, Actin polymerization and stabilization inducer
  • Description
    Actin polymerization and stabilization inducer. Cell-permeable.
  • Biological description
    Cell-permeable actin polymerization and stabilization inducer. Potent antiproliferative activity (IC50 = 15 nM). Antitumor and antifungal agent. Active in vitro.
  • Purity
    > 95%
  • CAS Number
    102396-24-7
  • Chemical structure
    Chemical Structure

Properties

  • Chemical name
    Cyclo[(3R)-3-(4-hydroxyphenyl)-β-alanyl-(2S,4E,6R,8S)-8-hydroxy-2,4,6-
    trimethyl-4-nonenoyl-L-alanyl-2-bromo-N-methyl-D-tryptophyl]
  • Molecular weight
    709.68
  • Molecular formula
    C36H45BrN4O6
  • PubChem identifier
    6436289
  • Storage instructions
    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in DMSO
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    C[C@@H]\1C[C@@H](OC(=O)C[C@@H](NC(=O)[C@H](N(C(=O)[C@@H](NC(=O)[C@@H](C/C(=C1)/C)C)C)C)CC2=C(NC3=CC=CC=C32)Br)C4=CC=C(C=C4)O)C
  • Source

    Jaspis splendens

  • Research areas

References

This product has been referenced in:
  • Holzinger A Jasplakinolide: an actin-specific reagent that promotes actin polymerization. Methods Mol Biol 586:71-87 (2009). Read more (PubMed: 19768425) »
  • Bubb MR  et al. Effects of jasplakinolide on the kinetics of actin polymerization. An explanation for certain in vivo observations. J Biol Chem 275:5163-70 (2000). Read more (PubMed: 10671562) »
  • Bubb MR  et al. Jasplakinolide, a cytotoxic natural product, induces actin polymerization and competitively inhibits the binding of phalloidin to F-actin. J Biol Chem 269:14869-71 (1994). Read more (PubMed: 8195116) »
See all 2 Publications for this product

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