Product nameJatrorrhizine, Phytochemical alkaloid
DescriptionPhytochemical alkaloid found in medicinal plants. Anti-inflammatory. Exhibits neuroprotective, antioxidative and gastrointestinal modulatory activities.
Novel tetrahydroisoquinoline alkaloid originally extracted from the Chinese herb Rhizoma Coptidis. Protects neuronal-like cells against H2O2-induced toxicity. Protects against okadaic acid induced oxidative toxicity through inhibiting the Mitogen-activated protein kinases pathways in HT22 hippocampal neurons. Displays neuroprotective effects against Aβ25-35-induced injury via its antioxidative potential. Potential therapeutic for gastrointestinal disorders.
Storage instructionsStore at +4°C. The product can be stored for up to 12 months.
Soluble in DMSO
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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This product has been referenced in:
- Jiang W et al. Jatrorrhizine Protects Against Okadaic Acid Induced Oxidative Toxicity Through Inhibiting the Mitogen-Activated Protein Kinases Pathways in HT22 Hippocampal Neurons. CNS Neurol Disord Drug Targets 14:1334-42 (2015). Read more (PubMed: 26295822) »
- Wu H et al. The antihypercholesterolemic effect of jatrorrhizine isolated from Rhizoma Coptidis. Phytomedicine 21:1373-81 (2014). Read more (PubMed: 24894270) »
- Luo T et al. The protective effects of jatrorrhizine on ß-amyloid (25-35)-induced neurotoxicity in rat cortical neurons. CNS Neurol Disord Drug Targets 11:1030-7 (2012). Read more (PubMed: 23244426) »
- Luo T et al. Neuroprotective effect of Jatrorrhizine on hydrogen peroxide-induced cell injury and its potential mechanisms in PC12 cells. Neurosci Lett 498:227-31 (2011). Read more (PubMed: 21605627) »