Jatrorrhizine, Phytochemical alkaloid (ab145577)

Overview

  • Product name

    Jatrorrhizine, Phytochemical alkaloid
  • Description

    Phytochemical alkaloid found in medicinal plants. Anti-inflammatory. Exhibits neuroprotective, antioxidative and gastrointestinal modulatory activities.
  • Alternative names

    • Jateorrhizine
    • Neprotin
    • Yatrorizine
  • Biological description

    Novel tetrahydroisoquinoline alkaloid originally extracted from the Chinese herb Rhizoma Coptidis. Protects neuronal-like cells against H2O2-induced toxicity. Protects against okadaic acid induced oxidative toxicity through inhibiting the Mitogen-activated protein kinases pathways in HT22 hippocampal neurons. Displays neuroprotective effects against Aβ25-35-induced injury via its antioxidative potential. Potential therapeutic for gastrointestinal disorders.

  • Purity

    > 98%
  • CAS Number

    3621-38-3
  • Chemical structure

    Chemical Structure

Properties

  • Molecular weight

    338.38
  • Molecular formula

    C20H20NO4X
  • Storage instructions

    Store at +4°C. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO

  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC(=C(C=C4CC3)O)OC)OC
  • Source

    Corydalis sp.

References

This product has been referenced in:

  • Jiang W  et al. Jatrorrhizine Protects Against Okadaic Acid Induced Oxidative Toxicity Through Inhibiting the Mitogen-Activated Protein Kinases Pathways in HT22 Hippocampal Neurons. CNS Neurol Disord Drug Targets 14:1334-42 (2015). Read more (PubMed: 26295822) »
  • Wu H  et al. The antihypercholesterolemic effect of jatrorrhizine isolated from Rhizoma Coptidis. Phytomedicine 21:1373-81 (2014). Read more (PubMed: 24894270) »
  • Luo T  et al. The protective effects of jatrorrhizine on ß-amyloid (25-35)-induced neurotoxicity in rat cortical neurons. CNS Neurol Disord Drug Targets 11:1030-7 (2012). Read more (PubMed: 23244426) »
  • Luo T  et al. Neuroprotective effect of Jatrorrhizine on hydrogen peroxide-induced cell injury and its potential mechanisms in PC12 cells. Neurosci Lett 498:227-31 (2011). Read more (PubMed: 21605627) »

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