Overview

  • Product name

    JIB 04, Jumonji histone demethylase inhibitor
  • Description

    Potent, selective, cell-permeable Jumonji histone demethylase inhibitor
  • Biological description

    Potent, selective, cell-permeable pan Jumonji histone demethylase inhibitor (IC50 values are 230, 340, 435, 445, 855 and 1100 nM for JARID1A, JMJD2E, JMJD2B, JMJD2A, JMJD3 and JMJD2C respectively). Selectively induces cancer death by altering transcriptional growth programs in cancer but not in normal cells. Shows antitumor effects in vivo.

  • Purity

    > 98%
  • CAS Number

    199596-05-9
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Wang L  et al. A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth. Nat Commun 4:2035 (2013). Read more (PubMed: 23792809) »
  • Easmon J  et al. Azinyl and diazinyl hydrazones derived from aryl N-heteroaryl ketones: synthesis and antiproliferative activity. J Med Chem 40:4420-5 (1997). Read more (PubMed: 9435912) »

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