Anti-JIP3 antibody (ab4545)
Key features and details
- Goat polyclonal to JIP3
- Suitable for: IHC-P
- Reacts with: Mouse
- Isotype: IgG
Overview
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Product name
Anti-JIP3 antibody
See all JIP3 primary antibodies -
Description
Goat polyclonal to JIP3 -
Host species
Goat -
Specificity
This antibody is expected to recognise both human isoforms of this protein. -
Tested applications
Suitable for: IHC-Pmore details -
Species reactivity
Reacts with: Mouse
Predicted to work with: Rat, Cow, Human -
Immunogen
Synthetic peptide:
MEIQMDEGGGVV
, corresponding to N terminal amino acids 2-13 of Human JIP3. -
General notes
GenBank Accession Number – NP_055948; NP_203750. LocusLink ID - 23162 (human); 30957 (mouse). Gene Ontology terms - vesicle-mediated transport; kinesin complex; cytoplasm; kinesin binding; MAP-kinase scaffold activity; protein kinase binding; regulation of JNK cascade.The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
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Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
Storage buffer
pH: 7.3
Preservative: 0.02% Sodium azide
Constituents: Tris buffered saline, 0.5% BSA -
Concentration information loading...
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Purity
Immunogen affinity purified -
Purification notes
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab4545 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
---|---|---|
IHC-P |
Use a concentration of 4 - 6 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
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Notes |
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IHC-P
Use a concentration of 4 - 6 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
Target
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Function
The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. May function as a regulator of vesicle transport, through interations with the JNK-signaling components and motor proteins. -
Sequence similarities
Belongs to the JIP scaffold family. -
Post-translational
modificationsPhosphorylated upon DNA damage, probably by ATM or ATR. -
Cellular localization
Cytoplasm. - Information by UniProt
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Database links
- Entrez Gene: 537598 Cow
- Entrez Gene: 23162 Human
- Entrez Gene: 30957 Mouse
- Entrez Gene: 302983 Rat
- Omim: 605431 Human
- SwissProt: Q9UPT6 Human
- SwissProt: Q9ESN9 Mouse
- Unigene: 207763 Human
see all -
Alternative names
- C-jun-amino-terminal kinase-interacting protein 3 antibody
- FLJ00027 antibody
- Homolog of Drosophila Sunday driver 2 antibody
see all
Images
Datasheets and documents
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Datasheet download
References (0)
ab4545 has not yet been referenced specifically in any publications.