Product nameJK 184, Hedgehog signaling inhibitor
DescriptionPotent Hedgehog signaling inhibitor
Biological descriptionPotent Hedgehog (Hh) signaling inhibitor. Inhibits alcohol dehydrogenase 7 (Adh7) (IC50 = 210 nM) and prevents Gli-dependent transcriptional activity (IC50 = 30 nM). Potently inhibits microtubule assembly. Additionally displays antitumor activity.
Storage instructionsStore at +4°C. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 100 mM and in ethanol to 25 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
- Pathways and Processes
- Metabolic signaling pathways
- Energy transfer pathways
- Energy Metabolism
This product has been referenced in:
- Cupido T et al. The imidazopyridine derivative JK184 reveals dual roles for microtubules in Hedgehog signaling. Angew Chem Int Ed Engl 48:2321-4 (2009). Read more (PubMed: 19222062) »
- Lee J et al. A small-molecule antagonist of the hedgehog signaling pathway. Chembiochem 8:1916-9 (2007). Read more (PubMed: 17886323) »