Anti-JMJD1C antibody (ab130922)
Key features and details
- Rabbit polyclonal to JMJD1C
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-JMJD1C antibody
See all JMJD1C primary antibodies -
Description
Rabbit polyclonal to JMJD1C -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Human -
Immunogen
Synthetic peptide corresponding to Human JMJD1C aa 150-250.
Database link: Q15652 -
Positive control
- WB: HeLa and 293T whole cell lysates.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C. -
Storage buffer
Preservative: 0.09% Sodium azide
Constituents: 99% Tris buffered saline, 0.1% BSA -
Concentration information loading...
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Purity
Immunogen affinity purified -
Purification notes
Purified using an epitope specific to JMJD1C immobilized on solid support. -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Positive Controls
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab130922 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
1/2000 - 1/10000. Predicted molecular weight: 284 kDa.
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Notes |
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WB
1/2000 - 1/10000. Predicted molecular weight: 284 kDa. |
Target
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Function
Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes. -
Sequence similarities
Belongs to the JHDM2 histone demethylase family.
Contains 1 JmjC domain. -
Domain
Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors. -
Post-translational
modificationsPhosphorylated upon DNA damage, probably by ATM or ATR. -
Cellular localization
Nucleus. - Information by UniProt
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Database links
- Entrez Gene: 221037 Human
- NCBI: NP_004232.2 Human
- Omim: 604503 Human
- SwissProt: Q15652 Human
- Unigene: 413416 Human
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Alternative names
- JHD2C_HUMAN antibody
- Jmjd1c antibody
- Jumonji domain containing 1C antibody
see all
Images
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All lanes : Anti-JMJD1C antibody (ab130922) at 0.04 µg/ml
Lane 1 : HeLa whole cell lysate at 50 µg
Lane 2 : HeLa whole cell lysate at 15 µg
Lane 3 : HeLa whole cell lysate at 5 µg
Lane 4 : 293T whole cell lysate at 15 µg
Developed using the ECL technique.
Predicted band size: 284 kDa
Exposure time: 3 minutes
Datasheets and documents
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Datasheet download
References (2)
ab130922 has been referenced in 2 publications.
- Qu F et al. Circular RNA circ_0006168 enhances Taxol resistance in esophageal squamous cell carcinoma by regulating miR-194-5p/JMJD1C axis. Cancer Cell Int 21:273 (2021). PubMed: 34022910
- Li CH et al. Expression pattern of JMJD1C in oocytes and its impact on early embryonic development. Genet Mol Res 14:18249-58 (2015). PubMed: 26782472