Overview

  • Product name

  • Description

    Rabbit polyclonal to JMJD1C
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-P, WBmore details
    Unsuitable for: IP
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide, corresponding to a region within amino acids 150-200 of Human JMJD1C (NP_004232.2).

  • Positive control

    • HeLa and 293T whole cell lysates.

Properties

Applications

Our Abpromise guarantee covers the use of ab130922 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use at an assay dependent concentration.
WB 1/2000 - 1/10000. Predicted molecular weight: 284 kDa.
  • Application notes
    Is unsuitable for IP.
  • Target

    • Function

      Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes.
    • Sequence similarities

      Belongs to the JHDM2 histone demethylase family.
      Contains 1 JmjC domain.
    • Domain

      Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors.
    • Post-translational
      modifications

      Phosphorylated upon DNA damage, probably by ATM or ATR.
    • Cellular localization

      Nucleus.
    • Information by UniProt
    • Database links

    • Alternative names

      • JHD2C_HUMAN antibody
      • Jmjd1c antibody
      • Jumonji domain containing 1C antibody
      • Jumonji domain-containing protein 1C antibody
      • Probable JmjC domain-containing histone demethylation protein 2C antibody
      • Thryoid receptor interacting protein antibody
      • Thyroid receptor-interacting protein 8 antibody
      • TR-interacting protein 8 antibody
      • TRIP-8 antibody
      • TRIP8 antibody
      see all

    Images

    • All lanes : Anti-JMJD1C antibody (ab130922) at 0.04 µg/ml

      Lane 1 : HeLa whole cell lysate at 50 µg
      Lane 2 : HeLa whole cell lysate at 15 µg
      Lane 3 : HeLa whole cell lysate at 5 µg
      Lane 4 : 293T whole cell lysate at 15 µg

      Developed using the ECL technique.

      Predicted band size: 284 kDa


      Exposure time: 3 minutes

    References

    ab130922 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

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