Overview

  • Product name
  • Description
    Rabbit polyclonal to JMJD5

    This product is a fast track antibody. It has been affinity purified and shows high titre values against the immunizing peptide by ELISA. Read the terms of use »

  • Host species
    Rabbit
  • Species reactivity

    Predicted to work with: Mouse, Rat, Cow, Human
  • Immunogen

    Synthetic peptide corresponding to Human JMJD5 aa 350 to the C-terminus conjugated to keyhole limpet haemocyanin.
    Database link: Q8N371
    (Peptide available as ab36103)

Properties

Target

  • Function
    Histone demethylase required for G2/M phase cell cycle progression. Specifically demethylates dimethylated 'Lys-36' (H3K36me2) of histone H3, an epigenetic repressive mark, thereby acting as a transcription activator. Regulates expression of CCNA1 (cyclin-A1), leading to regulate cancer cell proliferation.
  • Tissue specificity
    Weakly expressed in most cells. Highly expressed in breast cancer cells.
  • Sequence similarities
    Contains 1 JmjC domain.
  • Cellular localization
    Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • FLJ13798 antibody
    • JmjC domain-containing protein 5 antibody
    • JMJD5 antibody
    • JMJD5 protein antibody
    • jumonji domain containing 5 antibody
    • Jumonji domain-containing protein 5 antibody
    • KDM8_HUMAN antibody
    • Lysine (K) specific demethylase 8 antibody
    • Lysine-specific demethylase 8 antibody
    see all

References

This product has been referenced in:
  • Piao X  et al. Picroside II Shows Protective Functions for Severe Acute Pancreatitis in Rats by Preventing NF-?B-Dependent Autophagy. Oxid Med Cell Longev 2017:7085709 (2017). IHC . Read more (PubMed: 28713490) »
  • Lee CR  et al. Elevated expression of JMJD6 is associated with oral carcinogenesis and maintains cancer stemness properties. Carcinogenesis 37:119-128 (2016). Read more (PubMed: 26645717) »
See all 3 Publications for this product

Customer reviews and Q&As

Application
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Sample
Human Tissue sections (breast cancer)
Antigen retrieval step
Heat mediated - Buffer/Enzyme Used: Envision Flex Target Retrieval solution, low pH (Dako)
Permeabilization
No
Specification
breast cancer
Fixative
Formaldehyde

Abcam user community

Verified customer

Submitted Oct 23 2018

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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