Product nameJNJ-10198409, PDGF-BB tyrosine kinase inhibitor
DescriptionPotent ATP-competitive PDGF-BB tyrosine kinase inhibitor. Antiangiogenic agent.
Biological descriptionPotent ATP-competitive PDGF-BB tyrosine kinase inhibitor (IC50 = 4.2 nM). Antiangiogenic agent. Inhibits TGF-β1-mediated elongation and stiffening response. Selectively blocks Actn1 activation. Shows antiproliferative and antitumor effects in vivo. Orally active.
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in ethanol to 25 mM and in DMSO to 75 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
- Receptors & Transporters
- Enzyme-Linked Receptors
- Receptor tyrosine kinases
This product has been referenced in:
- Ghosh D et al. Integral role of platelet-derived growth factor in mediating transforming growth factor-ß1-dependent mesenchymal stem cell stiffening. Stem Cells Dev 23:245-61 (2014). Read more (PubMed: 24093435) »
- Hiram-Bab S et al. Platelet-derived growth factor BB mimics serum-induced dispersal of pancreatic epithelial cell clusters. J Cell Physiol 229:743-51 (2014). Read more (PubMed: 24129818) »
- Eichenbaum G et al. Oral coadministration of ß-glucuronidase to increase exposure of extensively glucuronidated drugs that undergo enterohepatic recirculation. J Pharm Sci 101:2545-56 (2012). Read more (PubMed: 22473491) »