JNJ-10198409, PDGF-BB tyrosine kinase inhibitor (ab144450)

Overview

  • Product name

    JNJ-10198409, PDGF-BB tyrosine kinase inhibitor
  • Description

    Potent ATP-competitive PDGF-BB tyrosine kinase inhibitor. Antiangiogenic agent.
  • Biological description

    Potent ATP-competitive PDGF-BB tyrosine kinase inhibitor (IC50 = 4.2 nM). Antiangiogenic agent. Inhibits TGF-β1-mediated elongation and stiffening response. Selectively blocks Actn1 activation. Shows antiproliferative and antitumor effects in vivo. Orally active.
  • Purity

    > 98%
  • CAS Number

    627512-69-0
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Ghosh D  et al. Integral role of platelet-derived growth factor in mediating transforming growth factor-ß1-dependent mesenchymal stem cell stiffening. Stem Cells Dev 23:245-61 (2014). Read more (PubMed: 24093435) »
  • Hiram-Bab S  et al. Platelet-derived growth factor BB mimics serum-induced dispersal of pancreatic epithelial cell clusters. J Cell Physiol 229:743-51 (2014). Read more (PubMed: 24129818) »
  • Eichenbaum G  et al. Oral coadministration of ß-glucuronidase to increase exposure of extensively glucuronidated drugs that undergo enterohepatic recirculation. J Pharm Sci 101:2545-56 (2012). Read more (PubMed: 22473491) »

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab144450.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
For licensing inquiries, please contact partnerships@abcam.com

Sign up