Overview

  • Product name

    JNJ-7777120, histamine H4 receptor antagonist
  • Description

    Potent, highly selective histamine H4 receptor antagonist
  • Biological description

    Potent, highly selective histamine H4 receptor antagonist (Ki = 4.5 nM). Shows anti-inflammatory, antifibrotic and antiallergic effects in vivo.
  • Purity

    > 98%
  • CAS Number

    459168-41-3
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Dib K  et al. The histamine H4 receptor is a potent inhibitor of adhesion-dependent degranulation in human neutrophils. J Leukoc Biol 96:411-8 (2014). Read more (PubMed: 24799603) »
  • Rosa AC  et al. Prevention of bleomycin-induced lung inflammation and fibrosis in mice by naproxen and JNJ7777120 treatment. J Pharmacol Exp Ther 351:308-16 (2014). Read more (PubMed: 25185215) »
  • Beermann S  et al. Opposite effects of mepyramine on JNJ 7777120-induced amelioration of experimentally induced asthma in mice in sensitization and provocation. PLoS One 7:e30285 (2012). Read more (PubMed: 22272324) »

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab144405.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
For licensing inquiries, please contact partnerships@abcam.com

Sign up