JSH 23, NFkappaB transcriptional activity inhibitor (ab144824)

Overview

  • Product name

    JSH 23, NFkappaB transcriptional activity inhibitor
  • Description

    NFκB transcriptional activity inhibitor
  • Biological description

    NFκB transcriptional activity inhibitor (IC50 = 7.1 μM). Inhibits LPS-induced nuclear translocation of NFκB. Does not affect IκB degradation. Potentiates the antitumor effects of cisplatin (ab141398). Shows neuroprotective effects in vivo.
  • Purity

    > 99%
  • CAS Number

    749886-87-1
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Kasparkova J  et al. Different affinity of nuclear factor-kappa B proteins to DNA modified by antitumor cisplatin and its clinically ineffective trans isomer. FEBS J 281:1393-408 (2014). Read more (PubMed: 24418212) »
  • de Vries EM  et al. NF?B signaling is essential for the lipopolysaccharide-induced increase of type 2 deiodinase in tanycytes. Endocrinology 155:2000-8 (2014). Read more (PubMed: 24635351) »
  • Kumar A  et al. JSH-23 targets nuclear factor-kappa B and reverses various deficits in experimental diabetic neuropathy: effect on neuroinflammation and antioxidant defence. Diabetes Obes Metab 13:750-8 (2011). Read more (PubMed: 21447040) »

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