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    jsh-23-nfkappab-transcriptional-activity-inhibitor-ab144824.pdf

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JSH 23, NFkappaB transcriptional activity inhibitor (ab144824)

  • Datasheet
  • SDS
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Chemical Structure - JSH 23, NFkappaB transcriptional activity inhibitor (ab144824)

    Key features and details

    • NFκB transcriptional activity inhibitor
    • CAS Number: 749886-87-1
    • Purity: > 99%
    • Soluble in ethanol to 75 mM and in DMSO to 100 mM
    • Form / State: Solid
    • Source: Synthetic

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    Overview

    • Product name

      JSH 23, NFkappaB transcriptional activity inhibitor
    • Description

      NFκB transcriptional activity inhibitor
    • Biological description

      NFκB transcriptional activity inhibitor (IC50 = 7.1 μM). Inhibits LPS-induced nuclear translocation of NFκB. Does not affect IκB degradation. Potentiates the antitumor effects of cisplatin (ab141398). Shows neuroprotective effects in vivo.
    • Purity

      > 99%
    • CAS Number

      749886-87-1
    • Chemical structure

      Chemical Structure

    Properties

    • Chemical name

      4-Methyl-1-N-(3-phenylpropyl)benzene-1,2-diamine
    • Molecular weight

      240.34
    • Molecular formula

      C16H20N2
    • PubChem identifier

      16760588
    • Storage instructions

      Store at -20°C (desiccating conditions).
    • Solubility overview

      Soluble in ethanol to 75 mM and in DMSO to 100 mM
    • Handling

      Toxic, refer to SDS for further information.

      Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

    • SMILES

      CC1=CC(=C(C=C1)NCCCC2=CC=CC=C2)N
    • Source

      Synthetic

    • Research areas

      • Biochemicals
      • Product Range
      • New
      • Biochemicals
      • Chemical Type
      • Biochemicals
      • Biochemicals
      • Pharmacology
      • Signaling
      • Signal transduction
      • Cytokines, NF-κB & IκB signaling

    Images

    • Chemical Structure - JSH 23, NFkappaB transcriptional activity inhibitor (ab144824)
      Chemical Structure - JSH 23, NFkappaB transcriptional activity inhibitor (ab144824)
      2D chemical structure image of ab144824, JSH 23, NFkappaB transcriptional activity inhibitor

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • SDS download

    • Datasheet download

      Download

    References (6)

    Publishing research using ab144824? Please let us know so that we can cite the reference in this datasheet.

    ab144824 has been referenced in 6 publications.

    • Nadeem L  et al. Pro-inflammatory signals induce 20a-HSD expression in myometrial cells: A key mechanism for local progesterone withdrawal. J Cell Mol Med 25:6773-6785 (2021). PubMed: 34114342
    • Cursano S  et al. A CRHR1 antagonist prevents synaptic loss and memory deficits in a trauma-induced delirium-like syndrome. Mol Psychiatry N/A:N/A (2020). PubMed: 32051550
    • Battaglia CR  et al. Corticotropin-releasing hormone (CRH) alters mitochondrial morphology and function by activating the NF-kB-DRP1 axis in hippocampal neurons. Cell Death Dis 11:1004 (2020). PubMed: 33230105
    • Kubota M  et al. Autophagy deficiency exacerbates colitis through excessive oxidative stress and MAPK signaling pathway activation. PLoS One 14:e0225066 (2019). PubMed: 31703091
    • Lai J  et al. Activation of NFKB-JMJD3 signaling promotes bladder fibrosis via boosting bladder smooth muscle cell proliferation and collagen accumulation. Biochim Biophys Acta Mol Basis Dis 1865:2403-2410 (2019). PubMed: 31102789
    • Barbero G  et al. An Autocrine Wnt5a Loop Promotes NF-?B Pathway Activation and Cytokine/Chemokine Secretion in Melanoma. Cells 8:N/A (2019). PubMed: 31510045

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