JSH 23, NFkappaB transcriptional activity inhibitor (ab144824)
Key features and details
- NFκB transcriptional activity inhibitor
- CAS Number: 749886-87-1
- Purity: > 99%
≥24 mg/mL in DMSO.
≥17.1 mg/mL in EtOH.
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
JSH 23, NFkappaB transcriptional activity inhibitor -
Description
NFκB transcriptional activity inhibitor -
Purity
> 99% -
CAS Number
749886-87-1 -
Chemical structure
Properties
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Chemical name
4-Methyl-1-N-(3-phenylpropyl)benzene-1,2-diamine
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Molecular weight
240.34 -
Molecular formula
C16H20N2 -
PubChem identifier
16760588 -
Storage instructions
Store at -20°C (desiccating conditions). -
Solubility overview
≥24 mg/mL in DMSO.
≥17.1 mg/mL in EtOH.
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Handling
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC1=CC(=C(C=C1)NCCCC2=CC=CC=C2)N -
Source
Synthetic
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Research areas
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (8)
ab144824 has been referenced in 8 publications.
- Mantsounga CS et al. Macrophage IL-1ß promotes arteriogenesis by autocrine STAT3- and NF-?B-mediated transcription of pro-angiogenic VEGF-A. Cell Rep 38:110309 (2022). PubMed: 35108537
- Smaldone G et al. KCTD15 deregulation is associated with alterations of the NF-?B signaling in both pathological and physiological model systems. Sci Rep 11:18237 (2021). PubMed: 34521919
- Nadeem L et al. Pro-inflammatory signals induce 20a-HSD expression in myometrial cells: A key mechanism for local progesterone withdrawal. J Cell Mol Med 25:6773-6785 (2021). PubMed: 34114342
- Cursano S et al. A CRHR1 antagonist prevents synaptic loss and memory deficits in a trauma-induced delirium-like syndrome. Mol Psychiatry N/A:N/A (2020). PubMed: 32051550
- Battaglia CR et al. Corticotropin-releasing hormone (CRH) alters mitochondrial morphology and function by activating the NF-kB-DRP1 axis in hippocampal neurons. Cell Death Dis 11:1004 (2020). PubMed: 33230105
- Kubota M et al. Autophagy deficiency exacerbates colitis through excessive oxidative stress and MAPK signaling pathway activation. PLoS One 14:e0225066 (2019). PubMed: 31703091
- Lai J et al. Activation of NFKB-JMJD3 signaling promotes bladder fibrosis via boosting bladder smooth muscle cell proliferation and collagen accumulation. Biochim Biophys Acta Mol Basis Dis 1865:2403-2410 (2019). PubMed: 31102789
- Barbero G et al. An Autocrine Wnt5a Loop Promotes NF-?B Pathway Activation and Cytokine/Chemokine Secretion in Melanoma. Cells 8:N/A (2019). PubMed: 31510045