Overview

  • Product name

  • Description

    Rabbit polyclonal to JTB
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide derived from the N terminal region of Human JTB.

  • Positive control

    • HUVEC cell lysate.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at -20ºC.
  • Storage buffer

    pH: 7.40
    Preservative: 0.02% Sodium azide
    Constituents: 49% PBS, 50% Glycerol, 0.88% Sodium chloride
    Note: PBS is without Mg2+ and Ca2+
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Purification notes

    ab137008 was affinity-purified from rabbit antiserum by immunogenic peptide affinity-chromatography.
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab137008 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 16 kDa.

Target

  • Function

    Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibits apoptosis induced by TGFB1 (By similarity). Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential.
  • Tissue specificity

    Ubiquitous. Expressed in all normal human tissues studied but overexpressed or underexpressed in many of their malignant counterparts.
  • Sequence similarities

    Belongs to the JTB family.
  • Cellular localization

    Membrane. Mitochondrion. Cytoplasm. Cytoplasm > cytoskeleton > centrosome. Cytoplasm > cytoskeleton > spindle. Detected at the centrosome and along spindle fibers during prophase and metaphase. Detected at the midbody during telophase.
  • Information by UniProt
  • Database links

  • Alternative names

    • hJT antibody
    • HJTB antibody
    • HSPC222 antibody
    • JTB antibody
    • JTB_HUMAN antibody
    • Jumping translocation breakpoint antibody
    • Jumping translocation breakpoint protein antibody
    • OTTHUMP00000034759 antibody
    • PAR antibody
    • PAR protein antibody
    • Prostate androgen regulated protein antibody
    • Prostate androgen-regulated protein antibody
    • Protein JTB antibody
    see all

Images

  • Anti-JTB antibody (ab137008) at 1/500 dilution + HUVEC cell lysate at 30 µg

    Predicted band size: 16 kDa

References

ab137008 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab137008.
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