Overview

  • Product name
    Anti-JTB antibody
    See all JTB primary antibodies
  • Description
    Mouse polyclonal to JTB
  • Host species
    Mouse
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Full length protein corresponding to Human JTB aa 1-146. (AAH00996).
    Sequence:

    MLAGAGRPGLPQGRHLCWLLCAFTLKLCQAEAPVQEEKLSASTSNLPCWL VEEFVVAEECSPCSNFRAKTTPECGPTGYVEKITCSSSKRNEFKSCRSAL MEQRLFWKFEGAVVCVALIFACLVIIRQRQLDRKALEKVRKQIESI


    Database link: O76095

    Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI
  • Positive control
    • JTB transfected 293T cell line lysate

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer
    pH: 7.2
    Constituent: 100% PBS
  • Concentration information loading...
  • Purity
    Protein A purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab172673 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 16 kDa.

Target

  • Function
    Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibits apoptosis induced by TGFB1 (By similarity). Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential.
  • Tissue specificity
    Ubiquitous. Expressed in all normal human tissues studied but overexpressed or underexpressed in many of their malignant counterparts.
  • Sequence similarities
    Belongs to the JTB family.
  • Cellular localization
    Membrane. Mitochondrion. Cytoplasm. Cytoplasm > cytoskeleton > centrosome. Cytoplasm > cytoskeleton > spindle. Detected at the centrosome and along spindle fibers during prophase and metaphase. Detected at the midbody during telophase.
  • Information by UniProt
  • Database links
    see all
  • Alternative names
    • hJT antibody
    • HJTB antibody
    • HSPC222 antibody
    • JTB antibody
    • JTB_HUMAN antibody
    • Jumping translocation breakpoint antibody
    • Jumping translocation breakpoint protein antibody
    • OTTHUMP00000034759 antibody
    • PAR antibody
    • PAR protein antibody
    • Prostate androgen regulated protein antibody
    • Prostate androgen-regulated protein antibody
    • Protein JTB antibody
    see all

Images

  • Western blot - Anti-JTB antibody (ab172673)
    Western blot - Anti-JTB antibody (ab172673)
    All lanes : Anti-JTB antibody (ab172673) at 1 µg/ml

    Lane 1 : JTB transfected 293T cell line lysate
    Lane 2 : Non-transfected 293T cell line lysate

    Lysates/proteins at 15 µl per lane.

    Developed using the ECL technique.

    Predicted band size: 16 kDa

References

ab172673 has not yet been referenced specifically in any publications.

Publishing research using ab172673? Please let us know so that we can cite the reference in this datasheet.

Customer reviews and Q&As

Submit a review Submit a question

There are currently no Customer reviews or Questions for ab172673.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

Sign up