Anti-JTB antibody (ab172673)

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Western blot - Anti-JTB antibody (ab172673)

    Key features and details

    • Mouse polyclonal to JTB
    • Suitable for: WB
    • Reacts with: Human
    • Isotype: IgG

    Overview

    • Product name

      Anti-JTB antibody
      See all JTB primary antibodies

    • Description

      Mouse polyclonal to JTB

    • Host species

      Mouse

    • Tested Applications & Species

      Application Species
      WB
      Human
      See all applications and species data

    • Immunogen

      Full length protein corresponding to Human JTB aa 1-146. (AAH00996).
      Sequence:

      MLAGAGRPGLPQGRHLCWLLCAFTLKLCQAEAPVQEEKLSASTSNLPCWL VEEFVVAEECSPCSNFRAKTTPECGPTGYVEKITCSSSKRNEFKSCRSAL MEQRLFWKFEGAVVCVALIFACLVIIRQRQLDRKALEKVRKQIESI


      Database link: O76095
      Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI

    • Positive control

      • JTB transfected 293T cell line lysate

    • General notes

      The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing the problem with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation.

      One factor contributing to the crisis is the use of antibodies that are not suitable. This can lead to misleading results and the use of incorrect data informing project assumptions and direction. To help address this challenge, we have introduced an application and species grid on our primary antibody datasheets to make it easy to simplify identification of the right antibody for your needs.

      Learn more here.

    Properties

    • Form

      Liquid

    • Storage instructions

      Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.

    • Storage buffer

      pH: 7.4
      Constituent: 100% PBS
    • Concentration information loading...

    • Purity

      Protein A purified

    • Clonality

      Polyclonal

    • Isotype

      IgG

    • Research areas

    Applications

    The Abpromise guarantee

    Our Abpromise guarantee covers the use of ab172673 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Guaranteed

    Tested applications are guaranteed to work and covered by our Abpromise guarantee.

    Predicted

    Predicted to work for this combination of applications and species but not guaranteed.

    Incompatible

    Does not work for this combination of applications and species.

    Application Species
    WB
    Human
    All applications
    Mouse
    Rat
    Application Abreviews Notes
    WB
    Use a concentration of 1 µg/ml. Predicted molecular weight: 16 kDa.
    Notes
    WB
    Use a concentration of 1 µg/ml. Predicted molecular weight: 16 kDa.

    Target

    • Function

      Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibits apoptosis induced by TGFB1 (By similarity). Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential.

    • Tissue specificity

      Ubiquitous. Expressed in all normal human tissues studied but overexpressed or underexpressed in many of their malignant counterparts.

    • Sequence similarities

      Belongs to the JTB family.

    • Cellular localization

      Membrane. Mitochondrion. Cytoplasm. Cytoplasm > cytoskeleton > centrosome. Cytoplasm > cytoskeleton > spindle. Detected at the centrosome and along spindle fibers during prophase and metaphase. Detected at the midbody during telophase.
    • Information by UniProt

    • Database links

      see all

    • Alternative names

      • hJT antibody
      • HJTB antibody
      • HSPC222 antibody
      • JTB antibody
      • JTB_HUMAN antibody
      • Jumping translocation breakpoint antibody
      • Jumping translocation breakpoint protein antibody
      • OTTHUMP00000034759 antibody
      • PAR antibody
      • PAR protein antibody
      • Prostate androgen regulated protein antibody
      • Prostate androgen-regulated protein antibody
      • Protein JTB antibody
      see all

    Images

    • Western blot - Anti-JTB antibody (ab172673)
      Western blot - Anti-JTB antibody (ab172673)
      All lanes : Anti-JTB antibody (ab172673) at 1 µg/ml

      Lane 1 : JTB transfected 293T cell line lysate
      Lane 2 : Non-transfected 293T cell line lysate

      Lysates/proteins at 15 µl per lane.

      Developed using the ECL technique.

      Predicted band size: 16 kDa

    References (0)

    Publishing research using ab172673? Please let us know so that we can cite the reference in this datasheet.

    ab172673 has not yet been referenced specifically in any publications.

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