Anti-JTB antibody (ab172673)
Key features and details
- Mouse polyclonal to JTB
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-JTB antibody
See all JTB primary antibodies -
Description
Mouse polyclonal to JTB -
Host species
Mouse -
Tested Applications & Species
Application Species WB Human -
Immunogen
Full length protein corresponding to Human JTB aa 1-146. (AAH00996).
Sequence:MLAGAGRPGLPQGRHLCWLLCAFTLKLCQAEAPVQEEKLSASTSNLPCWL VEEFVVAEECSPCSNFRAKTTPECGPTGYVEKITCSSSKRNEFKSCRSAL MEQRLFWKFEGAVVCVALIFACLVIIRQRQLDRKALEKVRKQIESI
Database link: O76095 -
Positive control
- JTB transfected 293T cell line lysate
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing the problem with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation.
One factor contributing to the crisis is the use of antibodies that are not suitable. This can lead to misleading results and the use of incorrect data informing project assumptions and direction. To help address this challenge, we have introduced an application and species grid on our primary antibody datasheets to make it easy to simplify identification of the right antibody for your needs.
Learn more here.
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.4
Constituent: 100% PBS -
Concentration information loading...
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Purity
Protein A purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab172673 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Tested applications are guaranteed to work and covered by our Abpromise guarantee.
Predicted to work for this combination of applications and species but not guaranteed.
Does not work for this combination of applications and species.
Application | Species |
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WB |
Human
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All applications |
Mouse
Rat
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Application | Abreviews | Notes |
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WB |
Use a concentration of 1 µg/ml. Predicted molecular weight: 16 kDa.
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Notes |
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WB
Use a concentration of 1 µg/ml. Predicted molecular weight: 16 kDa. |
Target
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Function
Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibits apoptosis induced by TGFB1 (By similarity). Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential. -
Tissue specificity
Ubiquitous. Expressed in all normal human tissues studied but overexpressed or underexpressed in many of their malignant counterparts. -
Sequence similarities
Belongs to the JTB family. -
Cellular localization
Membrane. Mitochondrion. Cytoplasm. Cytoplasm > cytoskeleton > centrosome. Cytoplasm > cytoskeleton > spindle. Detected at the centrosome and along spindle fibers during prophase and metaphase. Detected at the midbody during telophase. - Information by UniProt
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Database links
- Entrez Gene: 10899 Human
- Entrez Gene: 23922 Mouse
- Entrez Gene: 29439 Rat
- Omim: 604671 Human
- SwissProt: O76095 Human
- SwissProt: O88824 Mouse
- SwissProt: O88823 Rat
- Unigene: 6396 Human
see all -
Alternative names
- hJT antibody
- HJTB antibody
- HSPC222 antibody
see all
Images
Datasheets and documents
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SDS download
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Datasheet download
References (0)
ab172673 has not yet been referenced specifically in any publications.