Anti-JTB antibody (ab172673)
- Datasheet
- References
- Protocols
Overview
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Product name
Anti-JTB antibody
See all JTB primary antibodies -
Description
Mouse polyclonal to JTB -
Host species
Mouse -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse, Rat
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Immunogen
Full length protein corresponding to Human JTB aa 1-146. (AAH00996).
Sequence:MLAGAGRPGLPQGRHLCWLLCAFTLKLCQAEAPVQEEKLSASTSNLPCWL VEEFVVAEECSPCSNFRAKTTPECGPTGYVEKITCSSSKRNEFKSCRSAL MEQRLFWKFEGAVVCVALIFACLVIIRQRQLDRKALEKVRKQIESI
Database link: O76095 -
Positive control
- JTB transfected 293T cell line lysate
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.2
Constituent: 100% PBS -
Concentration information loading... -
Purity
Protein A purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
Our Abpromise guarantee covers the use of ab172673 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| WB | Use a concentration of 1 µg/ml. Predicted molecular weight: 16 kDa. |
Target
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Function
Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibits apoptosis induced by TGFB1 (By similarity). Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential. -
Tissue specificity
Ubiquitous. Expressed in all normal human tissues studied but overexpressed or underexpressed in many of their malignant counterparts. -
Sequence similarities
Belongs to the JTB family. -
Cellular localization
Membrane. Mitochondrion. Cytoplasm. Cytoplasm > cytoskeleton > centrosome. Cytoplasm > cytoskeleton > spindle. Detected at the centrosome and along spindle fibers during prophase and metaphase. Detected at the midbody during telophase. - Information by UniProt
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Database links
- Entrez Gene: 10899 Human
- Entrez Gene: 23922 Mouse
- Entrez Gene: 29439 Rat
- Omim: 604671 Human
- SwissProt: O76095 Human
- SwissProt: O88824 Mouse
- SwissProt: O88823 Rat
- Unigene: 6396 Human
see all -
Alternative names
- hJT antibody
- HJTB antibody
- HSPC222 antibody
see all
Images
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Western blot - Anti-JTB antibody (ab172673)All lanes : Anti-JTB antibody (ab172673) at 1 µg/ml
Lane 1 : JTB transfected 293T cell line lysate
Lane 2 : Non-transfected 293T cell line lysate
Lysates/proteins at 15 µl per lane.
Developed using the ECL technique.
Predicted band size: 16 kDa
Protocols
Datasheets and documents
References
ab172673 has not yet been referenced specifically in any publications.
