Regulates intracellular concentrations of taurine and glutamate. Negatively modulates SLC1A1/EAAC1 glutamate transport activity by decreasing its affinity for glutamate. May be involved in membrane traffic.
Belongs to the PRA1 family.
Endoplasmic reticulum membrane. Cytoplasm. Also exists as a soluble form in the cytoplasm. Associated with microtubules.
Lin J et al. JWA regulates human esophageal squamous cell carcinoma and human esophageal cells through different mitogen-activated protein kinase signaling pathways. Exp Ther Med7:1767-1771 (2014).
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