Overview

  • Product name

    JZL-184, monoacylglycerol lipase (MAGL) inhibitor
  • Description

    Potent, selective and irreversible inhibitor of monoacylglycerol lipase (MAGL)
  • Biological description

    Potent, selective and irreversible inhibitor of MAGL (IC50 values are 8 nM and 4 µM for MAGL and FAAH respectively). Cell-permeable. Potentiates DSE in cerebellar Purkinje neurons and DSI in hippocampal CA1 pyramidal neurons. Inhibits nociceptive processing and central sensitization in vivo.
  • Purity

    > 98%
  • CAS Number

    1101854-58-3
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    4-[Bis(1,3-benzodioxol-5-yl)-hydroxymethyl]piperidine-1-carboxylate 4-nitrophenyl ester
  • Molecular weight

    520.50
  • Molecular formula

    C27H24N2O9
  • PubChem identifier

    25021165
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 10 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1CN(CCC1C(C2=CC3=C(C=C2)OCO3)(C4=CC5=C(C=C4)OCO5)O)C(=O)OC6=CC=C(C=C6)[N+](=O)[O-]
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Woodhams SG  et al. Spinal administration of the monoacylglycerol lipase inhibitor JZL184 produces robust inhibitory effects on nociceptive processing and the development of central sensitization in the rat. Br J Pharmacol 167:1609-19 (2012). Read more (PubMed: 22924700) »
  • Crow JA  et al. Covalent inhibition of recombinant human carboxylesterase 1 and 2 and monoacylglycerol lipase by the carbamates JZL184 and URB597. Biochem Pharmacol 84:1215-22 (2012). Read more (PubMed: 22943979) »
  • Pan B  et al. Blockade of 2-arachidonoylglycerol hydrolysis by selective monoacylglycerol lipase inhibitor 4-nitrophenyl 4-(dibenzo[d][1,3]dioxol-5-yl(hydroxy)methyl)piperidine-1-carboxylate (JZL184) Enhances retrograde endocannabinoid signaling. J Pharmacol Exp Ther 331:591-7 (2009). Read more (PubMed: 19666749) »

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