JZL 195 hydrochloride, FAAH/MAGL inhibitor (ab144653)

Overview

  • Product name

    JZL 195 hydrochloride, FAAH/MAGL inhibitor
  • Description

    Potent dual FAAH/MAGL inhibitor
  • Biological description

    Potent dual FAAH/MAGL inhibitor. Shows analgesic effects in vivo. Centrally active. Blood-brain barrier permeable.
  • Purity

    > 99%
  • CAS Number

    1210004-12-8
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    4-[(3-Phenoxyphenyl)methyl]-1-piperazinecarboxylic acid 4-nitrophenyl ester hydrochloride
  • Molecular weight

    469.92
  • Molecular formula

    C24H23N3O5.HCl
  • PubChem identifier

    46232606
  • Storage instructions

    Store at -20°C (desiccating conditions).
  • Solubility overview

    Soluble in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    Cl.[O-][N+](=O)c1ccc(cc1)OC(=O)N4CCN(Cc3cc(Oc2ccccc2)ccc3)CC4
  • Source

    Synthetic

References

This product has been referenced in:

  • Anderson WB  et al. Actions of the dual FAAH/MAGL inhibitor JZL195 in a murine inflammatory pain model. Neuropharmacology 81C:224-230 (2013). Read more (PubMed: 24384256) »
  • Wise LE  et al. Dual fatty acid amide hydrolase and monoacylglycerol lipase blockade produces THC-like Morris water maze deficits in mice. ACS Chem Neurosci 3:369-78 (2012). Read more (PubMed: 22860205) »
  • Wiskerke J  et al. Characterization of the effects of reuptake and hydrolysis inhibition on interstitial endocannabinoid levels in the brain: an in vivo microdialysis study. ACS Chem Neurosci 3:407-17 (2012). Read more (PubMed: 22860210) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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