Key features and details
- Potent, highly selective CRF2 antagonist
- CAS Number: 434938-41-7
- Purity: > 98%
- Soluble in water
- Form / State: Solid
- Source: Synthetic
Product nameK 41498, CRF2 antagonist
DescriptionPotent, highly selective CRF2 antagonist
Potent and highly selective CRF2 antagonist (Ki values are 0.66, 0.62 and 425 nM at CRF2α,CRF2β and CRF1, respectively). Inhibits sauvagine-stimulated cAMP accumulation in hCRF2α- and hCRF2β-expressing cells in vitro. Able to block hypotension induced by urocortin following systemic administration.
SequenceFHLLRKXIEIEKQEKEKQQAANNRLLLDTI (Modifications: C-terminal amide; X-7 = Nle; Phe-1 = D-Phe)
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in water
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab141002 has not yet been referenced specifically in any publications.