Overview

  • Product name

    K252C, protein kinase C inhibitor
  • Description

    Potent, cell-permeable protein kinase C inhibitor
  • Biological description

    Potent, cell-permeable protein kinase C (PKC) inhibitor (IC50 are 2.45 and 25.7 μM for PKC and PKA respectively). Cytotoxic and antitumor agent. Active in vitro and in vivo.
  • Purity

    > 98%
  • CAS Number

    85753-43-1
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    6,7,12,13-Tetrahydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-5-one
  • Molecular weight

    311.34
  • Molecular formula

    C20H13N3O
  • PubChem identifier

    3815
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 25 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1C2=C3C4=CC=CC=C4NC3=C5C(=C2C(=O)N1)C6=CC=CC=C6N5
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Liu R  et al. Two indolocarbazole alkaloids with apoptosis activity from a marine-derived actinomycete Z(2)039-2. Arch Pharm Res 30:270-4 (2007). Read more (PubMed: 17424930) »
  • McGovern SL & Shoichet BK Kinase inhibitors: not just for kinases anymore. J Med Chem 46:1478-83 (2003). Read more (PubMed: 12672248) »
  • Pereira ER  et al. Structure-activity relationships in a series of substituted indolocarbazoles: topoisomerase I and protein kinase C inhibition and antitumoral and antimicrobial properties. J Med Chem 39:4471-7 (1996). Read more (PubMed: 8893841) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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