Overview

  • Product name

    Kahweol acetate, Glutathione S-transferase inducer
  • Description

    Glutathione S-transferase inducer
  • Biological description

    Glutathione S-transferase inducer. Inhibits tumor cell proliferation and induces apoptosis. Increases ROS production in tumor cells but not in normal cells. Shows chemopreventive effects in vivo. Orally active.
  • Purity

    > 98%
  • CAS Number

    81760-47-6
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    [(3bS,7R,8R,10aR,10bS)-7-hydroxy-10b-methyl-3b,4,5,6,7,8,9,10,10a,10b-decahydro-5a,8-methanocyclohepta[5,6]naphtho[2,1-b]furan-7-yl]methyl acetate
  • Molecular weight

    356.47
  • Molecular formula

    C22H28O4
  • PubChem identifier

    3260293
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC(=O)OCC1(CC23CCC4C5=C(C=CC4(C2CCC1C3)C)OC=C5)O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Cárdenas C  et al. Insights on the antitumor effects of kahweol on human breast cancer: Decreased survival and increased production of reactive oxygen species and cytotoxicity. Biochem Biophys Res Commun 447:452-8 (2014). Read more (PubMed: 24732357) »
  • Cavin C  et al. Cafestol and kahweol, two coffee specific diterpenes with anticarcinogenic activity. Food Chem Toxicol 40:1155-63 (2002). Read more (PubMed: 12067578) »
  • Lam LK  et al. Use of silver nitrate impregnated silica cartridges in the separation of kahweol and cafestol esters by preparative liquid chromatography. J Chromatogr 328:422-4 (1985). Read more (PubMed: 2993334) »

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