Key features and details
- Prototypic kainate receptor agonist. 1 ml water soluble pack.
- CAS Number: 487-79-6
- Purity: > 99%
- Soluble in 1ml of water to give specified mM/ml concentration
- Form / State: Solid
- Source: Digenea simplex
Product nameKainic acid (mM/ml), Prototypic kainate receptor agonist
DescriptionPrototypic kainate receptor agonist. 1 ml water soluble pack.
Prototypic agonist at the kainate class of ionotropic glutamate receptors. Potent excitant and neurotoxin, used to model epilepsy and neurodegenerative states.
Soluble in 1 ml water to give specified mM/ml concentration. Find out more.
Chemical name(2S,3S,4S)-3-(Carboxymethyl)-4-(prop-1-en-2-yl)pyrrolidine-2-carboxylic acid
Storage instructionsStore at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in 1ml of water to give specified mM/ml concentration
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
2D chemical structure image of ab144490, Kainic acid (mM/ml), Prototypic kainate receptor agonist
Immunocytochemistry/ Immunofluorescence analysis of microglial cells in the stratum radiatum of the CA1 region of the hippocampus of CX3CR1egfp/+ mice in control conditions (left) or 48 hours after status epilepticus (SE) induced by intra-peritoneal injection of kainate (right). Each image is a maximum intensity z-projection of 31 confocal slices for a total thickness of 12 µm.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab144490 has been referenced in 32 publications.
- Wong SJ et al. Effects of selective auditory-nerve damage on the behavioral audiogram and temporal integration in the budgerigar. Hear Res 374:24-34 (2019). PubMed: 30703625
- Tischbein M et al. The RNA-binding protein FUS/TLS undergoes calcium-mediated nuclear egress during excitotoxic stress and is required for GRIA2 mRNA processing. J Biol Chem 294:10194-10210 (2019). PubMed: 31092554
- Shi C et al. Melatonin Mitigates Kainic Acid-Induced Neuronal Tau Hyperphosphorylation and Memory Deficits through Alleviating ER Stress. Front Mol Neurosci 11:5 (2018). PubMed: 29416502
- Maroto M et al. Chondroitin sulfate, a major component of the perineuronal net, elicits inward currents, cell depolarization, and calcium transients by acting on AMPA and kainate receptors of hippocampal neurons. J Neurochem : (2013). PubMed: 23350646
- Hunfeld M et al. Effects of anesthetic agents on seizure-induction with intra-cortical injection of convulsants. Epilepsy Res 105:52-61 (2013). PubMed: 23357722