- References (45)
Product nameKainic acid, prototypic kainate receptor agonist
DescriptionPrototypic kainate receptor agonist
Biological descriptionPrototypic agonist at the kainate class of ionotropic glutamate receptors. Potent excitant and neurotoxin, used to model epilepsy and neurodegenerative states. Also available in Kit(s): Ionotropic agonists (ab120323).
Also available in simple stock solutions (ab144490) - add 1 ml of water to get an exact, ready-to-use concentration.
Chemical name(2S,3S,4S)-3-(Carboxymethyl)-4-(prop-1-en-2-yl)pyrrolidine-2-carboxylic acid
Storage instructionsStore at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in water to 25 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Our Abpromise guarantee covers the use of ab120100 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|Functional Studies||Use at an assay dependent concentration.|
This product has been referenced in:
- Wang Q et al. Kainic acid-mediated excitotoxicity as a model for neurodegeneration. Mol Neurobiol 31:3-16 (2005). Read more (PubMed: 15953808) »
- Hampson DR & Manalo JL The activation of glutamate receptors by kainic acid and domoic acid. Nat Toxins 6:153-8 (1998). Read more (PubMed: 10223631) »
- Nadler JV Minireview. Kainic acid as a tool for the study of temporal lobe epilepsy. Life Sci 29:2031-42 (1981). Read more (PubMed: 7031398) »