Overview

  • Product name

    Anti-Kallikrein 11 antibody
    See all Kallikrein 11 primary antibodies
  • Description

    Rabbit polyclonal to Kallikrein 11
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to a sequence at the C terminal of Human Kallikrein 11.

  • Positive control

    • Human prostatic cancer tissue; M231, M453, Jurkat, COLO320 and HT1080 cell lysates.

Properties

Applications

Our Abpromise guarantee covers the use of ab131038 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.1 - 0.5 µg/ml. Predicted molecular weight: 31 kDa.
IHC-P Use a concentration of 0.5 - 1 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

Target

  • Function

    Possible multifunctional protease. Efficiently cleaves 'bz-Phe-Arg-4-methylcoumaryl-7-amide', a kallikrein substrate, and weakly cleaves other substrates for kallikrein and trypsin. Cleaves synthetic peptides after arginine but not lysine residues.
  • Tissue specificity

    Expressed in brain, skin and prostate. Isoform 1 is expressed preferentially in brain. Isoform 2 is expressed in prostate. Present in seminal plasma at concentrations ranging from 2 to 37 microg/mL (at protein level).
  • Sequence similarities

    Belongs to the peptidase S1 family. Kallikrein subfamily.
    Contains 1 peptidase S1 domain.
  • Post-translational
    modifications

    About 40% of KLK11 is inactivated by internal cleavage after Arg-188. This proteolytic inactivation may be effected by plasminogen.
  • Cellular localization

    Secreted.
  • Information by UniProt
  • Database links

  • Alternative names

    • Hippostasin antibody
    • hK11 antibody
    • Kallikrein 11 antibody
    • Kallikrein 11 isoform 1 preproprotein antibody
    • Kallikrein 11 isoform 2 precursor antibody
    • Kallikrein 11 precursor antibody
    • Kallikrein related peptidase 11 antibody
    • Kallikrein-11 inactive chain 2 antibody
    • KLK 11 antibody
    • Klk11 antibody
    • KLK11_HUMAN antibody
    • MGC33060 antibody
    • Protease serine 20 trypsin like antibody
    • Protease serine trypsin like antibody
    • PRSS20 antibody
    • Serine protease 20 antibody
    • TLSP antibody
    • Trypsin like protease antibody
    • Trypsin-like protease antibody
    see all

Images

  • All lanes : Anti-Kallikrein 11 antibody (ab131038) at 0.1 µg/ml

    Lane 1 : M231 cell lysate
    Lane 2 : M453 cell lysate
    Lane 3 : Jurkat cell lysate
    Lane 4 : COLO320 cell lysate
    Lane 5 : HT1080 cell lysate
    Lane 6 : COLO320 Cell Lysate
    Lane 7 : JURKAT Cell Lysate

    Predicted band size: 31 kDa

  • Immunohistochemical analysis of paraffin-embedded Human prostatic cancer tissue labelling Kallikrein 11 with ab131038 at 0.5 µg/ml.

References

This product has been referenced in:

  • Geng X  et al. Elevated tumor tissue protein expression levels of kallikrein-related peptidases KLK10 and KLK11 are associated with a better prognosis in advanced high-grade serous ovarian cancer patients. Am J Cancer Res 8:1856-1864 (2018). Read more (PubMed: 30323977) »
See 1 Publication for this product

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab131038.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
For licensing inquiries, please contact partnerships@abcam.com

Sign up