Anti-Kallikrein 5 antibody (ab7283)

Submit a review Q&A (3)References (4)

Key features and details

  • Rabbit polyclonal to Kallikrein 5
  • Suitable for: WB
  • Isotype: IgG

Overview

  • Product name

    Anti-Kallikrein 5 antibody
    See all Kallikrein 5 primary antibodies

  • Description

    Rabbit polyclonal to Kallikrein 5

  • Host species

    Rabbit

  • Tested applications

    Suitable for: WBmore details

  • Immunogen

    Synthetic peptide, corresponding to amino acids 280-293 of Human KLK5.

Properties

Applications

Our Abpromise guarantee covers the use of ab7283 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Detects a band of approximately 32 kDa.

Target

  • Function

    May be involved in desquamation.

  • Tissue specificity

    Expressed in skin, breast, brain and testis. Expressed at the stratum granulosum of palmar skin.

  • Sequence similarities

    Belongs to the peptidase S1 family. Kallikrein subfamily.
    Contains 1 peptidase S1 domain.

  • Cellular localization

    Secreted.
  • Information by UniProt

  • Alternative names

    • HK5 antibody
    • Kallikrein 5 antibody
    • Kallikrein L2 antibody
    • Kallikrein like 2 antibody
    • Kallikrein like protein 2 antibody
    • Kallikrein related peptidase 5 antibody
    • Kallikrein-5 antibody
    • Kallikrein-like protein 2 antibody
    • Kallikrein5 antibody
    • KLK 5 antibody
    • KLK L2 antibody
    • KLK-L2 antibody
    • KLK5 antibody
    • KLK5_HUMAN antibody
    • KLKL 2 antibody
    • KLKL2 antibody
    • SCTE antibody
    • Stratum corneum tryptic enzyme antibody
    • UNQ570/PRO1132 antibody
    see all

References

Publishing research using ab7283? Please let us know so that we can cite the reference in this datasheet.

ab7283 has been referenced in 4 publications.

  • Furio L  et al. Transgenic kallikrein 5 mice reproduce major cutaneous and systemic hallmarks of Netherton syndrome. J Exp Med 211:499-513 (2014). PubMed: 24534191
  • Bonnart C  et al. Elastase 2 is expressed in human and mouse epidermis and impairs skin barrier function in Netherton syndrome through filaggrin and lipid misprocessing. J Clin Invest 120:871-82 (2010). IHC-P ; Human . PubMed: 20179351
  • Yanagi T  et al. Self-improvement of keratinocyte differentiation defects during skin maturation in ABCA12-deficient harlequin ichthyosis model mice. Am J Pathol 177:106-18 (2010). WB, IHC-P ; Mouse . PubMed: 20489143
  • Di WL  et al. A heterozygous null mutation combined with the G1258A polymorphism of SPINK5 causes impaired LEKTI function and abnormal expression of skin barrier proteins. Br J Dermatol 161:404-12 (2009). WB ; Human . PubMed: 19438860

Customer reviews and Q&As

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1-3 of 3 Abreviews or Q&A

Question

Je souhaite commander les références ab7283 et ab96710 mais je souhaiterai savoir si ces 2 anticorps reconnaitront la forme active de la kallikrein5 et kallikrein7.

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Answer

L’immunogène d’ab7283 correspond aux acides amines 280-293 de la protéine kallikrein 5 humaine. Ces acides aminés sont présents chez la forme active de la protéine.

L’immunogène d’ab96710 se trouve dans les acides aminés 30-253 de la protéine kallikrein 7 qui est la forme active de la protéine.

Je peux donc vous confirmer que ces deux anticorps reconnaissent à la fois les formes actives et non actives de ces protéines.

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Question

Hi is it possible for you to email me copies of the relevant msds for the following antibodies please?
Ab7283

Ab80790

Ab63982

Ab64892

Ab24722

Ab64409

Ab45091

Kind regards
.

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Answer

Thank you for contacting us.
Please find attached the Material Safety Datasheet for some of the products requested. Those products not containing any hazardous products do not require MSDS.
If by any chance you required these datasheets for legal requirements, please do not hesitate to let me know, as we can still prepare it for you.

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Question

In the datasheet one can find the applicaton note, that it works in western blot. Does this mean under native or under denaturing conditions? Also the Abreview from Douglas Taylor about western blot with this ab doesn´t tell, if it was made under native or denatured conditions. I´m asking, because we are searching now since quite a space of time for an ab against KLK5, which functions in paraffin-embedded tissue sections. Thanks a lot for your assistance and patience.

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Answer

Thank you for your enquiry. The antibody ab7283 has been tested in standard reducing conditions in western blotting and has not been tested in IHC-P. It may work in IHC-P and should you decide to go ahead and purchase this product, please let us know how you get on by submitting an Abreview and in return we will offer you 50 Abpoints which can be redeemed on a number of rewards (a further 100 Abpoints will be offered for an image).

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