Overview

  • Product name

    Anti-Kallikrein 6 antibody
    See all Kallikrein 6 primary antibodies
  • Description

    Goat polyclonal to Kallikrein 6
  • Host species

    Goat
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Monkey, Gorilla
  • Immunogen

    Synthetic peptide corresponding to Human Kallikrein 6 aa 145-156 (internal sequence) (Cysteine residue).
    Sequence:

    KTADGDFPDTIQ


    Database link: Q92876

  • Positive control

    • Human prostate and kidney tissues.
  • General notes

    Preliminary experiments gave an approx 50kDa band in Human Ovary lysates after 0.5 µg/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 26.9kDa according to NP_002765.1. The 50kDa band was successfully blocked by incubation with the immunizing peptide.

Properties

Applications

Our Abpromise guarantee covers the use of ab191281 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 5 µg/ml.

Target

  • Function

    Serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. Degrades alpha-synuclein and prevents its polymerization, indicating that it may be involved in the pathogenesis of Parkinson disease and other synucleinopathies. May be involved in regulation of axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis.
  • Tissue specificity

    In fluids, highest levels found in milk of lactating women followed by cerebrospinal fluid, nipple aspirate fluid and breast cyst fluid. Also found in serum, seminal plasma and some amniotic fluids and breast tumor cytosolic extracts. Not detected in urine. At the tissue level, highest concentrations found in glandular tissues such as salivary glands followed by lung, colon, fallopian tube, placenta, breast, pituitary and kidney. Not detected in skin, spleen, bone, thyroid, heart, ureter, liver, muscle, endometrium, testis, pancreas, seminal vesicle, ovary, adrenals and prostate. In brain, detected in gray matter neurons (at protein level). Colocalizes with pathological inclusions such as Lewy bodies and glial cytoplasmic inclusions. Overexpressed in primary breast tumors but not expressed in metastatic tumors.
  • Sequence similarities

    Belongs to the peptidase S1 family. Kallikrein subfamily.
    Contains 1 peptidase S1 domain.
  • Post-translational
    modifications

    Inactivated by autolytic cleavage after Arg-80.
  • Cellular localization

    Secreted. Nucleus > nucleolus. Cytoplasm. Mitochondrion. Microsome. In brain, detected in the nucleus of glial cells and in the nucleus and cytoplasm of neurons. Detected in the mitochondrial and microsomal fractions of HEK-293 cells and released into the cytoplasm following cell stress.
  • Information by UniProt
  • Database links

  • Alternative names

    • Bssp antibody
    • hK 6 antibody
    • hK6 antibody
    • Kallikrein 6 precursor antibody
    • Kallikrein related peptidase 6 antibody
    • Kallikrein-6 antibody
    • Kallikrein6 antibody
    • KLK 6 antibody
    • Klk 7 antibody
    • KLK 9 antibody
    • Klk29 antibody
    • Klk6 antibody
    • KLK6_HUMAN antibody
    • Klk7 antibody
    • KLK9 antibody
    • MGC9355 antibody
    • mGK 1 antibody
    • mGK1 antibody
    • MSP antibody
    • Neurosin antibody
    • Protease M antibody
    • Protease serine 18 antibody
    • Protease serine 9 antibody
    • PRSS 18 antibody
    • PRSS 9 antibody
    • PRSS18 antibody
    • PRSS9 antibody
    • Serine protease 18 antibody
    • Serine protease 9 antibody
    • SP 59 antibody
    • SP59 antibody
    • Tissue kallikrein antibody
    • TK antibody
    • Zyme antibody
    see all

Images

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human prostate tissue labeling Kallikrein 6 with ab191281 at 5 µg/ml.

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human kidney tissue labeling Kallikrein 6 with ab191281 at 5 µg/ml.

References

ab191281 has not yet been referenced specifically in any publications.

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