Anti-Kallikrein 7/KLK7 antibody (ab200745)
Key features and details
- Rabbit polyclonal to Kallikrein 7/KLK7
- Suitable for: WB
- Reacts with: Mouse, Rat, Human
- Isotype: IgG
Overview
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Product name
Anti-Kallikrein 7/KLK7 antibody
See all Kallikrein 7/KLK7 primary antibodies -
Description
Rabbit polyclonal to Kallikrein 7/KLK7 -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Mouse, Rat, Human -
Immunogen
Synthetic peptide within Human Kallikrein 7/KLK7 aa 1-100. The exact immunogen sequence used to generate this antibody is proprietary information. If additional detail on the immunogen is needed to determine the suitability of the antibody for your needs, please contact our Scientific Support team to discuss your requirements.
Database link: P49862 -
Positive control
- HEK293T, sp2/0 and PC12 whole cell lysate
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.20
Preservative: 0.097% Sodium azide
Constituent: 99% PBS -
Concentration information loading...
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Purity
Immunogen affinity purified -
Purification notes
Purity is > 95% (by SDS-PAGE). -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Related Products
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab200745 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
---|---|---|
WB |
1/500 - 1/1000. Predicted molecular weight: 28 kDa.
|
Notes |
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WB
1/500 - 1/1000. Predicted molecular weight: 28 kDa. |
Target
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Function
May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. SCCE cleaves insulin B chain at '6-Leu-
-Cys-7', '16-Tyr-
-Leu-17', '25-Phe-
-Tyr-26' and '26-Tyr-
-Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines. -
Tissue specificity
Abundantly expressed in the skin and is expressed by keratinocytes in the epidermis. Also expressed in the brain, mammary gland, cerebellum, spinal cord and kidney. Lower levels in salivary glands, uterus, thymus, thyroid, placenta, trachea and testis. Up-regulated in ovarian carcinoma, especially late-stage serous carcinoma, compared with normal ovaries and benign adenomas (at protein level). -
Sequence similarities
Belongs to the peptidase S1 family. Kallikrein subfamily.
Contains 1 peptidase S1 domain. -
Cellular localization
Secreted. In ovarian carcinoma, secreted and also observed at the apical membrane and in cytoplasm at the invasive front. - Information by UniProt
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Database links
- Entrez Gene: 5650 Human
- Entrez Gene: 23993 Mouse
- Entrez Gene: 292852 Rat
- Omim: 604438 Human
- SwissProt: P49862 Human
- SwissProt: Q91VE3 Mouse
- SwissProt: P36373 Rat
- Unigene: 151254 Human
see all -
Alternative names
- Chymotryptic stratum corneum antibody
- hK 7 antibody
- hK7 antibody
see all
Images
Datasheets and documents
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Datasheet download
References (1)
ab200745 has been referenced in 1 publication.
- Zhang Y et al. LncRNA FOXD2-AS1 accelerates the papillary thyroid cancer progression through regulating the miR-485-5p/KLK7 axis. J Cell Biochem 120:7952-7961 (2019). PubMed: 30456805