Overview

  • Product name
    Anti-Kallikrein 7 antibody
    See all Kallikrein 7 primary antibodies
  • Description
    Rabbit polyclonal to Kallikrein 7
  • Host species
    Rabbit
  • Specificity
    Detects endogenous levels of Kallikrein 7 protein.
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide within Human Kallikrein 7 aa 20-65. The exact sequence is proprietary.
    Sequence:

    T AGEEAQGDKI IDGAPCARGS HPWQVALLSG NQLHCGGVLV NERWV


    Database link: P49862

  • Positive control
    • HEK293T, sp2/0 and PC12 whole cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab200745 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use at an assay dependent concentration. Predicted molecular weight: 28 kDa.

Target

  • Function
    May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. SCCE cleaves insulin B chain at '6-Leu-
    -Cys-7', '16-Tyr-
    -Leu-17', '25-Phe-
    -Tyr-26' and '26-Tyr-
    -Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines.
  • Tissue specificity
    Abundantly expressed in the skin and is expressed by keratinocytes in the epidermis. Also expressed in the brain, mammary gland, cerebellum, spinal cord and kidney. Lower levels in salivary glands, uterus, thymus, thyroid, placenta, trachea and testis. Up-regulated in ovarian carcinoma, especially late-stage serous carcinoma, compared with normal ovaries and benign adenomas (at protein level).
  • Sequence similarities
    Belongs to the peptidase S1 family. Kallikrein subfamily.
    Contains 1 peptidase S1 domain.
  • Cellular localization
    Secreted. In ovarian carcinoma, secreted and also observed at the apical membrane and in cytoplasm at the invasive front.
  • Information by UniProt
  • Database links
  • Alternative names
    • Chymotryptic stratum corneum antibody
    • hK 7 antibody
    • hK7 antibody
    • hSCCE antibody
    • Kallikrein 7 (chymotryptic stratum corneum) antibody
    • Kallikrein related peptidase 7 antibody
    • Kallikrein-7 antibody
    • Kallikrein7 antibody
    • KLK 7 antibody
    • Klk7 antibody
    • KLK7_HUMAN antibody
    • Protease serine 6 antibody
    • PRSS 6 antibody
    • PRSS6 antibody
    • SCCE antibody
    • Serine protease 6 antibody
    • Signal protein antibody
    • Stratum corneum chymotryptic enzyme antibody
    see all

Images

  • All lanes : Anti-Kallikrein 7 antibody (ab200745)

    Lane 1 : HEK293T whole cell lysate
    Lane 2 : sp2/0 whole cell lysate
    Lane 3 : PC12 whole cell lysate

    Predicted band size: 28 kDa

References

ab200745 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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