Overview

  • Product name

    Kanamycin B, Broad spectrum aminoglycoside antibiotic
  • Description

    Broad spectrum aminoglycoside antibiotic
  • Biological description

    Broad spectrum aminoglycoside antibiotic. Binds to 70S ribosomal subunit. Inhibits protein synthesis. Kanamycin A (ab141946) analog. Shows reversible neuromuscular blocking effects in vivo.
  • Purity

    > 98%
  • CAS Number

    4696-76-8
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (2R,3S,4R,5R,6R)-5-Amino-2-(aminomethyl)-6-[(1R,2S,3S,4R,6S)-4,
    6-diamino-3-[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxyoxane-3,4-diol
  • Molecular weight

    483.51
  • Molecular formula

    C18H37N5O10
  • PubChem identifier

    439318
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1C(C(C(C(C1N)OC2C(C(C(C(O2)CO)O)N)O)O)OC3C(C(C(C(O3)CN)O)O)N)N
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Ni X  et al. Construction of kanamycin B overproducing strain by genetic engineering of Streptomyces tenebrarius. Appl Microbiol Biotechnol 89:723-31 (2011). Read more (PubMed: 20936279) »
  • Kwon M  et al. In vitro selection of RNA against kanamycin B. Mol Cells 11:303-11 (2001). Read more (PubMed: 11459219) »
  • Griffey RH  et al. Determinants of aminoglycoside-binding specificity for rRNA by using mass spectrometry. Proc Natl Acad Sci U S A 96:10129-33 (1999). Read more (PubMed: 10468574) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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