Kanamycin sulfate, Aminoglycoside antibiotic agent (ab145633)
- Datasheet
- References
Overview
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Product name
Kanamycin sulfate, Aminoglycoside antibiotic agent -
Description
Aminoglycoside antibiotic agent -
Biological description
Aminoglycoside antibiotic agent. Irreversibly binds bacterial 30S ribosomal subunit. Causes misreading of t-RNA. Inhibits protein synthesis. Active against aerobic, Gram-negative bacteria and some mycobacteria in vivo. Often used to select for bacteria which have been successfully transformed with a plasmid conferring kanamycin resistance. -
Purity
> 95% -
CAS Number
25389-94-0 -
Chemical structure
Properties
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Chemical name
(2R,3S,4S,5R,6R)-2-(Aminomethyl)-6-[(1R,2R,3S,4R,6S)-4,6-diamino-3-[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxyoxane-3,4,5-triol sulfate -
Molecular weight
582.58 -
Molecular formula
C18H36N4O11.H2SO4 -
PubChem identifier
441374 -
Storage instructions
Store at +4°C. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 75 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C1[C@H]([C@@H]([C@H]([C@@H]([C@H]1N)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CN)O)O)O)O)O[C@@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)N)O)N.OS(=O)(=O)O -
Source
Streptomyces kanamyceticus
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Research areas
References
This product has been referenced in:
- Gutiérrez-Huante M et al. Bicarbonate enhances the in vitro antibiotic activity of kanamycin in Escherichia coli. Lett Appl Microbiol 60:440-6 (2015). Read more (PubMed: 25585891) »
- Dridi B et al. Differences in Antibiotic-Induced Oxidative Stress Responses between Laboratory and Clinical Isolates of Streptococcus pneumoniae. Antimicrob Agents Chemother 59:5420-6 (2015). Read more (PubMed: 26100702) »
- Shrestha SK et al. Antifungal amphiphilic aminoglycoside K20: bioactivities and mechanism of action. Front Microbiol 5:671 (2014). Read more (PubMed: 25538692) »
