Anti-KAT2A / GCN5 antibody [AT3G13] (ab208097)
Key features and details
- Mouse monoclonal [AT3G13] to KAT2A / GCN5
- Suitable for: WB, ICC/IF
- Reacts with: Human
- Isotype: IgG2a
Overview
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Product name
Anti-KAT2A / GCN5 antibody [AT3G13]
See all KAT2A / GCN5 primary antibodies -
Description
Mouse monoclonal [AT3G13] to KAT2A / GCN5 -
Host species
Mouse -
Tested applications
Suitable for: WB, ICC/IFmore details -
Species reactivity
Reacts with: Human -
Immunogen
Recombinant fragment corresponding to Human KAT2A/ GCN5 aa 400 to the C-terminus.
Database link: Q92830 -
Positive control
- HeLa cells and HeLa whole cell lysate (ab150035).
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General notes
Derived from hybridization of mouse F0 myeloma cells.
This product was changed from ascites to tissue culture supernatant on 28/02/19. Please note that the dilutions may need to be adjusted accordingly. If you have any questions, please do not hesitate to contact our scientific support team.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: 89% PBS, 10% Glycerol -
Concentration information loading...
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Purity
Protein G purified -
Clonality
Monoclonal -
Clone number
AT3G13 -
Isotype
IgG2a -
Light chain type
kappa -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Positive Controls
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Recombinant Protein
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Related Products
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab208097 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
1/250 - 1/1000. Predicted molecular weight: 94 kDa.
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ICC/IF |
1/250 - 1/500.
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Notes |
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WB
1/250 - 1/1000. Predicted molecular weight: 94 kDa. |
ICC/IF
1/250 - 1/500. |
Target
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Function
Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Acetylation of histones gives a specific tag for epigenetic transcription activation. Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. -
Tissue specificity
Expressed in all tissues tested, with most abundant expression in ovary. -
Sequence similarities
Belongs to the GCN5 family.
Contains 1 bromo domain.
Contains 1 N-acetyltransferase domain. -
Cellular localization
Nucleus. - Information by UniProt
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Database links
- Entrez Gene: 2648 Human
- Omim: 602301 Human
- SwissProt: Q92830 Human
- Unigene: 463045 Human
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Alternative names
- 1110051E14Rik antibody
- AW212720 antibody
- EC 2.3.1.48 antibody
see all
Images
Protocols
Datasheets and documents
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SDS download
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Datasheet download
References (2)
ab208097 has been referenced in 2 publications.
- Liao W et al. Upregulation of GPNCA is associated with poor prognosis through enhancement of tumor growth via regulating GSK3B. Sci Rep 10:2044 (2020). PubMed: 32029792
- Cramer T et al. Early-life epigenetic changes along the corticotropin-releasing hormone (CRH) gene influence resilience or vulnerability to heat stress later in life. Mol Psychiatry 24:1013-1026 (2019). PubMed: 30742007