Overview

  • Product name

    Anti-KAT2A / GCN5 antibody
    See all KAT2A / GCN5 primary antibodies
  • Description

    Rabbit polyclonal to KAT2A / GCN5
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Mouse, Human
    Predicted to work with: Rat, Chicken
  • Immunogen

    Synthetic peptide, corresponding to a region within C terminal amino acids 775-837 of Human KAT2A/ GCN5 (UniProt ID: Q92830).

  • Positive control

    • A431, H1299 and HeLa whole cell lysates.

Properties

Applications

Our Abpromise guarantee covers the use of ab137515 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 94 kDa.

Target

  • Function

    Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Acetylation of histones gives a specific tag for epigenetic transcription activation. Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.
  • Tissue specificity

    Expressed in all tissues tested, with most abundant expression in ovary.
  • Sequence similarities

    Belongs to the GCN5 family.
    Contains 1 bromo domain.
    Contains 1 N-acetyltransferase domain.
  • Cellular localization

    Nucleus.
  • Information by UniProt
  • Database links

  • Alternative names

    • 1110051E14Rik antibody
    • AW212720 antibody
    • EC 2.3.1.48 antibody
    • GCN 5 antibody
    • GCN5 (general control of amino-acid synthesis, yeast, homolog)-like 2 antibody
    • Gcn5 antibody
    • GCN5 general control of amino-acid synthesis 5-like 2 (yeast) antibody
    • GCN5L2 antibody
    • general control of amino acid synthesis 5-like 2 antibody
    • General control of amino acid synthesis protein 5-like 2 antibody
    • General control of amino acid synthesis, yeast, homolog-like 2 antibody
    • HGCN5 antibody
    • Histone acetyltransferase GCN5 antibody
    • Histone acetyltransferase KAT2A antibody
    • hsGCN5 antibody
    • K(lysine) acetyltransferase 2A antibody
    • KAT2 A antibody
    • KAT2A antibody
    • KAT2A_HUMAN antibody
    • Lysine acetyltransferase 2A antibody
    • MGC102791 antibody
    • PCAF-b antibody
    • STAF97 antibody
    see all

Images

  • All lanes : Anti-KAT2A / GCN5 antibody (ab137515) at 1/1000 dilution

    Lane 1 : A431 whole cell lysate
    Lane 2 : H1299 whole cell lysate
    Lane 3 : HeLa whole cell lysate

    Lysates/proteins at 30 µg per lane.

    Predicted band size: 94 kDa



    7.5% SDS PAGE

References

This product has been referenced in:

  • Stilling RM  et al. K-Lysine acetyltransferase 2a regulates a hippocampal gene expression network linked to memory formation. EMBO J 33:1912-27 (2014). Mouse . Read more (PubMed: 25024434) »
See 1 Publication for this product

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