The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use at an assay dependent concentration.
1/500. Predicted molecular weight: 94 kDa.
1/100 - 1/400.
Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Acetylation of histones gives a specific tag for epigenetic transcription activation. Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.
Expressed in all tissues tested, with most abundant expression in ovary.
Belongs to the GCN5 family. Contains 1 bromo domain. Contains 1 N-acetyltransferase domain.
GCN5 (general control of amino-acid synthesis, yeast, homolog)-like 2 antibody
GCN5 general control of amino-acid synthesis 5-like 2 (yeast) antibody
general control of amino acid synthesis 5-like 2 antibody
General control of amino acid synthesis protein 5-like 2 antibody
General control of amino acid synthesis, yeast, homolog-like 2 antibody
Histone acetyltransferase GCN5 antibody
Histone acetyltransferase KAT2A antibody
K(lysine) acetyltransferase 2A antibody
KAT2 A antibody
Lysine acetyltransferase 2A antibody
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-KAT2A / GCN5 antibody (ab18381)This image is courtesy of an anonymous Abreview
ab18381 at 2ug/ml staining human spleen tissue sections by Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections). The tissue was fixed and blocked and incubated with the antibody for 30 minutes. An HRP conjugated goat antibody was used as the secondary.
Yi Q et al. Islet-1 induces the differentiation of mesenchymal stem cells into cardiomyocyte-like cells through the regulation of Gcn5 and DNMT-1. Mol Med Rep15:2511-2520 (2017).
Read more (PubMed: 28447752) »
Liu Y et al. Akt kinase targets the association of CBP with histone H3 to regulate the acetylation of lysine K18. FEBS Lett587:847-53 (2013).
Read more (PubMed: 23434580) »