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Epigenetics and Nuclear Signaling Chromatin Modifying Enzymes Acetylation
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Anti-KAT2A / GCN5 antibody - C-terminal (ab153903)

  • Datasheet
  • SDS
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Western blot - Anti-KAT2A / GCN5 antibody - C-terminal (ab153903)
  • Western blot - Anti-KAT2A / GCN5 antibody - C-terminal (ab153903)
  • Immunocytochemistry/ Immunofluorescence - Anti-KAT2A / GCN5 antibody - C-terminal (ab153903)

Key features and details

  • Rabbit polyclonal to KAT2A / GCN5 - C-terminal
  • Suitable for: WB, ICC/IF
  • Reacts with: Mouse, Human
  • Isotype: IgG

You may also be interested in

Protein
Product image
Recombinant human KAT2A / GCN5 protein (ab198084)
Secondary
Product image
Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

View more associated products

Overview

  • Product name

    Anti-KAT2A / GCN5 antibody - C-terminal
    See all KAT2A / GCN5 primary antibodies
  • Description

    Rabbit polyclonal to KAT2A / GCN5 - C-terminal
  • Host species

    Rabbit
  • Tested Applications & Species

    Application Species
    ICC/IF
    Human
    WB
    Mouse
    Human
    See all applications and species data
  • Immunogen

    Recombinant fragment, corresponding to a region within C terminal amino acids 589-810 of Human KAT2A/ GCN5.

  • Positive control

    • IMR32, NIH3T3, JC and BCL-1 whole cell lysates; MCF7 cells.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.00
    Preservative: 0.01% Thimerosal (merthiolate)
    Constituents: 78.99% PBS, 1% BSA, 20% Glycerol (glycerin, glycerine)
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

    • Epigenetics and Nuclear Signaling
    • Chromatin Modifying Enzymes
    • Acetylation
    • Epigenetics and Nuclear Signaling
    • Transcription
    • Co-factors
    • Epigenetics and Nuclear Signaling
    • Chromatin Modifying Enzymes
    • Acetylation
    • HAT
    • Epigenetics and Nuclear Signaling
    • Bromodomains

Associated products

  • Compatible Secondaries

    • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
    • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
  • Isotype control

    • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)
  • Positive Controls

    • NIH/3T3 whole cell lysate (ab7179)
  • Recombinant Protein

    • Recombinant human KAT2A / GCN5 protein (ab198084)
  • Related Products

    • Recombinant Human KAT2A / GCN5 protein (ab111648)

Applications

The Abpromise guarantee

Our Abpromise guarantee covers the use of ab153903 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Guaranteed

Tested applications are guaranteed to work and covered by our Abpromise guarantee.

Predicted

Predicted to work for this combination of applications and species but not guaranteed.

Incompatible

Does not work for this combination of applications and species.

Application Species
ICC/IF
Human
WB
Mouse
Human
All applications
Rat
Chicken
Application Abreviews Notes
WB
1/500 - 1/3000. Predicted molecular weight: 94 kDa.
ICC/IF
1/100 - 1/1000.
Notes
WB
1/500 - 1/3000. Predicted molecular weight: 94 kDa.
ICC/IF
1/100 - 1/1000.

Target

  • Function

    Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Acetylation of histones gives a specific tag for epigenetic transcription activation. Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.
  • Tissue specificity

    Expressed in all tissues tested, with most abundant expression in ovary.
  • Sequence similarities

    Belongs to the GCN5 family.
    Contains 1 bromo domain.
    Contains 1 N-acetyltransferase domain.
  • Cellular localization

    Nucleus.
  • Target information above from: UniProt accession Q92830 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links

    • Entrez Gene: 374232 Chicken
    • Entrez Gene: 2648 Human
    • Entrez Gene: 14534 Mouse
    • Entrez Gene: 303539 Rat
    • Omim: 602301 Human
    • SwissProt: Q92830 Human
    • SwissProt: Q9JHD2 Mouse
    • Unigene: 463045 Human
    • Unigene: 218837 Mouse
    see all
  • Alternative names

    • 1110051E14Rik antibody
    • AW212720 antibody
    • EC 2.3.1.48 antibody
    • GCN 5 antibody
    • GCN5 (general control of amino-acid synthesis, yeast, homolog)-like 2 antibody
    • Gcn5 antibody
    • GCN5 general control of amino-acid synthesis 5-like 2 (yeast) antibody
    • GCN5L2 antibody
    • general control of amino acid synthesis 5-like 2 antibody
    • General control of amino acid synthesis protein 5-like 2 antibody
    • General control of amino acid synthesis, yeast, homolog-like 2 antibody
    • HGCN5 antibody
    • Histone acetyltransferase GCN5 antibody
    • Histone acetyltransferase KAT2A antibody
    • hsGCN5 antibody
    • K(lysine) acetyltransferase 2A antibody
    • KAT2 A antibody
    • KAT2A antibody
    • KAT2A_HUMAN antibody
    • Lysine acetyltransferase 2A antibody
    • MGC102791 antibody
    • PCAF-b antibody
    • STAF97 antibody
    see all

Images

  • Western blot - Anti-KAT2A / GCN5 antibody - C-terminal (ab153903)
    Western blot - Anti-KAT2A / GCN5 antibody - C-terminal (ab153903)
    Anti-KAT2A / GCN5 antibody - C-terminal (ab153903) at 1/1000 dilution + IMR32 whole cell lysate at 30 µg

    Predicted band size: 94 kDa



    7.5% SDS PAGE
  • Western blot - Anti-KAT2A / GCN5 antibody - C-terminal (ab153903)
    Western blot - Anti-KAT2A / GCN5 antibody - C-terminal (ab153903)
    All lanes : Anti-KAT2A / GCN5 antibody - C-terminal (ab153903) at 1/1000 dilution

    Lane 1 : NIH3T3 whole cell lysate
    Lane 2 : JC whole cell lysate
    Lane 3 : BCL-1 whole cell lysate

    Lysates/proteins at 30 µg per lane.

    Predicted band size: 94 kDa



    7.5% SDS PAGE
  • Immunocytochemistry/ Immunofluorescence - Anti-KAT2A / GCN5 antibody - C-terminal (ab153903)
    Immunocytochemistry/ Immunofluorescence - Anti-KAT2A / GCN5 antibody - C-terminal (ab153903)
    Immunofluorescent analysis of paraformaldehyde-fixed MCF7 cells labeling KAT2A / GCN5 with ab153903 at 1/500 dilution. Lower panel co-stained with Hoechst 33342.

Protocols

  • Western blot protocols
  • Immunocytochemistry & immunofluorescence protocols

Click here to view the general protocols

Datasheets and documents

    • Datasheet
    • SDS
  • References (1)

    Publishing research using ab153903? Please let us know so that we can cite the reference in this datasheet.

    ab153903 has been referenced in 1 publication.

    • Torres-Zelada EF  et al. The Drosophila Dbf4 ortholog Chiffon forms a complex with Gcn5 that is necessary for histone acetylation and viability. J Cell Sci 132:N/A (2019). PubMed: 30559249

    Customer reviews and Q&As

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