Anti-KAT6B / MORF antibody (ab191994)
Key features and details
- Rabbit polyclonal to KAT6B / MORF
- Suitable for: WB
- Reacts with: Mouse, Human
- Isotype: IgG
Overview
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Product name
Anti-KAT6B / MORF antibody
See all KAT6B / MORF primary antibodies -
Description
Rabbit polyclonal to KAT6B / MORF -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Mouse, Human -
Immunogen
Synthetic peptide within Human KAT6B/ MORF. The exact sequence is proprietary.
Database link: Q8WYB5 -
Positive control
- HEK293T, Raw264.7 and NIH 3T3 whole cell lysates.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.20
Preservative: 0.05% Sodium azide
Constituent: 99% PBS -
Concentration information loading...
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Purity
Immunogen affinity purified -
Purification notes
ab191994 was affinity-purified from Rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE). -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Positive Controls
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab191994 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
1/500. Predicted molecular weight: 231 kDa.
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Notes |
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WB
1/500. Predicted molecular weight: 231 kDa. |
Target
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Function
Histone acetyltransferase which may be involved in both positive and negative regulation of transcription. Required for RUNX2-dependent transcriptional activation. May be involved in cerebral cortex development. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. -
Tissue specificity
Ubiquitously expressed, with high levels in heart, pancreas, testis and ovary. -
Involvement in disease
Note=A chromosomal aberration involving MYST4 may be a cause acute myeloid leukemias. Translocation t(10;16)(q22;p13) with CREBBP. -
Sequence similarities
Belongs to the MYST (SAS/MOZ) family.
Contains 1 C2HC-type zinc finger.
Contains 1 H15 (linker histone H1/H5 globular) domain.
Contains 2 PHD-type zinc fingers. -
Domain
The N-terminus is involved in transcriptional activation while the C-terminus is involved in transcriptional repression. -
Post-translational
modificationsAutoacetylated. -
Cellular localization
Nucleus. - Information by UniProt
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Database links
- Entrez Gene: 23522 Human
- Entrez Gene: 54169 Mouse
- Omim: 605880 Human
- SwissProt: Q8WYB5 Human
- SwissProt: Q8BRB7 Mouse
- Unigene: 35758 Human
- Unigene: 599543 Human
- Unigene: 248967 Mouse
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Alternative names
- DKFZp313G1618 antibody
- FLJ90335 antibody
- Histone acetyltransferase MORF antibody
see all
Images
Datasheets and documents
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Datasheet download
References (1)
ab191994 has been referenced in 1 publication.
- Wu Y et al. High methylation of lysine acetyltransferase 6B is associated with the Cobb angle in patients with congenital scoliosis. J Transl Med 18:210 (2020). PubMed: 32448279