Overview

  • Product name

    Anti-KAT6B / MORF antibody
    See all KAT6B / MORF primary antibodies
  • Description

    Rabbit polyclonal to KAT6B / MORF
  • Host species

    Rabbit
  • Specificity

    This antibody reacts with MORF and MORF alpha.
  • Tested applications

    Suitable for: WB, IHC-P, IPmore details
  • Species reactivity

    Reacts with: Cow, Human
  • Immunogen

    Synthetic peptide corresponding to Cow KAT6B/ MORF (N terminal) conjugated to keyhole limpet haemocyanin.
    Database link: A7E390

Properties

Applications

Our Abpromise guarantee covers the use of ab58823 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/7500. Detects a band of approximately 230 kDa (predicted molecular weight: 231 kDa).
IHC-P 1/1000.
IP Use at an assay dependent concentration.

Target

  • Function

    Histone acetyltransferase which may be involved in both positive and negative regulation of transcription. Required for RUNX2-dependent transcriptional activation. May be involved in cerebral cortex development. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.
  • Tissue specificity

    Ubiquitously expressed, with high levels in heart, pancreas, testis and ovary.
  • Involvement in disease

    Note=A chromosomal aberration involving MYST4 may be a cause acute myeloid leukemias. Translocation t(10;16)(q22;p13) with CREBBP.
  • Sequence similarities

    Belongs to the MYST (SAS/MOZ) family.
    Contains 1 C2HC-type zinc finger.
    Contains 1 H15 (linker histone H1/H5 globular) domain.
    Contains 2 PHD-type zinc fingers.
  • Domain

    The N-terminus is involved in transcriptional activation while the C-terminus is involved in transcriptional repression.
  • Post-translational
    modifications

    Autoacetylated.
  • Cellular localization

    Nucleus.
  • Information by UniProt
  • Database links

  • Alternative names

    • DKFZp313G1618 antibody
    • FLJ90335 antibody
    • Histone acetyltransferase MORF antibody
    • Histone acetyltransferase MOZ2 antibody
    • Histone acetyltransferase MYST4 antibody
    • KAT 6B antibody
    • KIAA0383 antibody
    • Monocytic leukemia zinc finger protein related factor antibody
    • Monocytic leukemia zinc finger protein-related factor antibody
    • MOZ 2 antibody
    • MOZ antibody
    • MOZ related factor antibody
    • MOZ YBF2/SAS3 SAS2 and TIP60 protein 4 antibody
    • MOZ2 antibody
    • MYST 4 antibody
    • MYST histone acetyltransferase (monocytic leukemia) 4 antibody
    • MYST protein 4 antibody
    • MYST-4 antibody
    • MYST4 antibody
    • MYST4_HUMAN antibody
    • OTTHUMP00000019866 antibody
    • OTTHUMP00000019867 antibody
    • OTTHUMP00000019869 antibody
    • OTTHUMP00000019870 antibody
    • QKF antibody
    • Querkopf antibody
    • SAS2 and TIP60 protein 4 antibody
    • YBF2/SAS3 antibody
    see all

References

This product has been referenced in:

  • Ding H  et al. MicroRNA-4513 Promotes Gastric Cancer Cell Proliferation and Epithelial-Mesenchymal Transition Through Targeting KAT6B. Hum Gene Ther Clin Dev 30:142-148 (2019). Read more (PubMed: 31310159) »
  • Simpson MA  et al. De novo mutations of the gene encoding the histone acetyltransferase KAT6B cause Genitopatellar syndrome. Am J Hum Genet 90:290-4 (2012). WB . Read more (PubMed: 22265017) »
See all 3 Publications for this product

Customer reviews and Q&As

1-2 of 2 Abreviews or Q&A

Question
Answer

The peptide used to produce this antibody is 90% conserved in a mouse, therefore the antibody is likely to react with mouse.

Read More

Answer

Thank you for your interest in these products. The secondary antibody used in the study was not from abcam but we do have several similar products in stock. ab6721 is a goat polyclonal to rabbit IgG and has been used extensively in Western blotting which should be suitable for your experiments. It costs £125 and if ordered today will be delivered by Thursday the 29th of September. The study also used an anti-beta actin antibody as a loading control (ab8227)purchased from abcam which you may also be interested in. Please note that if you want to participate in the testing discount for ab58823 by sharing the figure produced from your experiments (entitles you to a free primary antibody of your choice) you need to let me know prior to purchasing the antibody so that I can issue you with a discount code. More details of this offer are available here (please note that although the antibody you are interested in has been tested for the application and species you are interested in, this is a new offer and only requires you provide us with an image for an antibody which we currently do not have an image for such as ab58823 through an Abreview): https://www.abcam.com/index.html?pageconfig=resource&rid=11998&viapagetrap=collaborationdiscount If you have any further queries please let me know.

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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