Key features and details
- Rabbit polyclonal to KAT7 / Hbo1 / MYST2
- Suitable for: WB
- Reacts with: Mouse, Rat, Human
- Isotype: IgG
Product nameAnti-KAT7 / Hbo1 / MYST2 antibody
See all KAT7 / Hbo1 / MYST2 primary antibodies
DescriptionRabbit polyclonal to KAT7 / Hbo1 / MYST2
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Mouse, Rat, Human
Synthetic peptide corresponding to Human KAT7/ Hbo1/ MYST2 (N terminal).
Database link: O95251
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Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage bufferPreservative: 0.02% Thimerosal (merthiolate)
Constituents: 1% BSA, 50% Glycerol, PBS
Concentration information loading...
PurityProtein A purified
Our Abpromise guarantee covers the use of ab37289 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||Use a concentration of 1 - 4 µg/ml. Detects a band of approximately 65 kDa (predicted molecular weight: 65 kDa).|
FunctionComponent of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may regulate DNA replication and act as a coactivator of TP53-dependent transcription. Specifically represses AR-mediated transcription.
Tissue specificityUbiquitously expressed, with highest levels in testis.
Sequence similaritiesBelongs to the MYST (SAS/MOZ) family.
Contains 1 C2HC-type zinc finger.
DomainThe C2HC-type zinc finger is required for interaction with MCM2 and ORC1L.
The N-terminus is involved in transcriptional repression, while the C-terminus mediates AR-interaction.
modificationsPhosphorylated upon DNA damage, probably by ATM or ATR.
Cellular localizationNucleus > nucleoplasm.
- Information by UniProt
- Hbo 1 antibody
- HBO1 antibody
- HBOa antibody
ab37289 has been referenced in 2 publications.
- Schrötter A et al. FE65 regulates and interacts with the Bloom syndrome protein in dynamic nuclear spheres - potential relevance to Alzheimer's disease. J Cell Sci 126:2480-92 (2013). PubMed: 23572515
- Kueh AJ et al. HBO1 Is Required for H3K14 Acetylation and Normal Transcriptional Activity during Embryonic Development. Mol Cell Biol 31:845-860 (2011). IHC-P ; Mouse . PubMed: 21149574