Overview

  • Product name

  • Description

    Rabbit polyclonal to KATNB1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Recombinant fragment corresponding to Human KATNB1 aa 429-578. (BC001353)

  • Positive control

    • Human fetal stomach tissue; Human fetal heart and fetal brain lysates.
  • General notes

     This product was previously labelled as Katanin p80

     

Properties

  • Form

    Lyophilised:Add 200ul sterile distilled water.
  • Storage instructions

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer

    pH: 7.20
    Preservative: 0.02% Sodium azide
    Constituents: 1% BSA, 98% PBS
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Purification notes

    ab118219 is purified by a protein affinity column.
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab118219 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/2000. Detects a band of approximately 72 kDa (predicted molecular weight: 72 kDa).
IHC-P 1/100 - 1/500.

Target

  • Function

    Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.
  • Sequence similarities

    Belongs to the WD repeat KATNB1 family.
    Contains 6 WD repeats.
  • Cellular localization

    Cytoplasm. Cytoplasm > cytoskeleton > centrosome. Cytoplasm > cytoskeleton > spindle pole. Cytoplasm > cytoskeleton. Predominantly cytoplasmic. Localized to the interphase centrosome and mitotic spindle poles.
  • Information by UniProt
  • Database links

  • Alternative names

    • KAT antibody
    • Katanin (80 kDa) antibody
    • Katanin p80 (WD repeat containing) subunit B 1 antibody
    • Katanin p80 subunit B 1 antibody
    • Katanin p80 subunit B1 antibody
    • Katanin p80 WD40-containing subunit B1 antibody
    • katnb1 antibody
    • KTNB1_HUMAN antibody
    • OTTHUMP00000164672 antibody
    • p80 katanin antibody
    see all

Images

  • All lanes : Anti-KATNB1 antibody (ab118219) at 1/1000 dilution

    Lane 1 : Human fetal brain lysate
    Lane 2 : Human fetal heart lysate

    Predicted band size: 72 kDa

  • ab118219 at 1/100 dilution staining KATNB1 in Formalin-fixed, Paraffin-embedded Human fetal stomach tissue by Immunohistochemistry. Note cytoplasmic staining.

References

ab118219 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab118219.
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